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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NR1H2
All Species:
37.88
Human Site:
S114
Identified Species:
69.44
UniProt:
P55055
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55055
NP_009052.3
461
51102
S114
C
K
G
F
F
R
R
S
V
V
R
G
G
A
R
Chimpanzee
Pan troglodytes
XP_512838
512
55356
S114
C
K
G
F
F
R
R
S
V
V
R
G
G
A
R
Rhesus Macaque
Macaca mulatta
XP_001115995
461
51038
S114
C
K
G
F
F
R
R
S
V
V
R
G
G
A
R
Dog
Lupus familis
XP_851316
455
50496
S112
C
K
G
F
F
R
R
S
V
V
R
G
G
A
R
Cat
Felis silvestris
Mouse
Mus musculus
Q60644
446
49701
S105
C
K
G
F
F
R
R
S
V
V
H
G
G
A
G
Rat
Rattus norvegicus
Q62755
446
49717
S105
C
K
G
F
F
R
R
S
V
V
H
G
G
A
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517956
624
68359
S302
C
K
G
F
F
R
R
S
V
I
K
G
A
R
Y
Chicken
Gallus gallus
NP_989873
409
47037
S87
C
K
G
F
F
R
R
S
V
I
K
G
A
Q
Y
Frog
Xenopus laevis
P28699
476
53015
M93
Q
S
T
S
S
E
E
M
V
P
S
S
P
S
P
Zebra Danio
Brachydanio rerio
Q9PTN2
453
50848
F94
K
A
S
F
T
C
P
F
N
G
N
C
T
I
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P34021
878
93835
S291
C
K
G
F
F
R
R
S
V
T
K
S
A
V
Y
Honey Bee
Apis mellifera
NP_001091685
629
66768
S276
C
K
G
F
F
R
R
S
I
T
K
N
A
V
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001123279
490
55735
S124
C
K
G
F
F
R
R
S
I
T
K
N
A
K
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
75.9
98.6
93.9
N.A.
88
88.9
N.A.
51.5
63.7
24.3
32.3
N.A.
23.2
32.1
N.A.
38.9
Protein Similarity:
100
79.3
98.9
95.6
N.A.
90.8
90.8
N.A.
60
73.2
40.7
53.4
N.A.
33.9
45.9
N.A.
56.5
P-Site Identity:
100
100
100
100
N.A.
86.6
86.6
N.A.
66.6
66.6
6.6
6.6
N.A.
60
53.3
N.A.
53.3
P-Site Similarity:
100
100
100
100
N.A.
86.6
86.6
N.A.
80
80
13.3
6.6
N.A.
66.6
66.6
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
0
0
0
0
0
0
39
47
0
% A
% Cys:
85
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
8
8
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
93
85
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
85
0
0
0
0
0
0
8
0
62
47
0
16
% G
% His:
0
0
0
0
0
0
0
0
0
0
16
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
16
16
0
0
0
8
0
% I
% Lys:
8
85
0
0
0
0
0
0
0
0
39
0
0
8
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
8
0
8
16
0
0
0
% N
% Pro:
0
0
0
0
0
0
8
0
0
8
0
0
8
0
8
% P
% Gln:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% Q
% Arg:
0
0
0
0
0
85
85
0
0
0
31
0
0
8
31
% R
% Ser:
0
8
8
8
8
0
0
85
0
0
8
16
0
8
0
% S
% Thr:
0
0
8
0
8
0
0
0
0
24
0
0
8
0
8
% T
% Val:
0
0
0
0
0
0
0
0
77
47
0
0
0
16
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
39
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _