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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF5
All Species:
54.24
Human Site:
Y313
Identified Species:
74.58
UniProt:
P55010
Number Species:
16
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55010
NP_001960.2
431
49223
Y313
N
N
K
K
A
Q
R
Y
L
L
H
G
L
E
C
Chimpanzee
Pan troglodytes
XP_001135628
431
49234
Y313
N
N
K
K
A
Q
R
Y
L
L
H
G
L
E
C
Rhesus Macaque
Macaca mulatta
XP_001086107
510
58170
Y392
N
N
K
K
A
Q
R
Y
L
L
H
G
L
E
C
Dog
Lupus familis
XP_854659
425
48689
Y307
N
N
K
K
A
Q
R
Y
L
L
H
G
L
E
C
Cat
Felis silvestris
Mouse
Mus musculus
P59325
429
48950
Y311
N
N
K
K
A
Q
R
Y
L
L
H
G
L
E
C
Rat
Rattus norvegicus
Q07205
429
48936
Y311
N
N
K
K
A
Q
R
Y
L
L
H
G
L
E
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507766
428
48873
Y310
N
N
K
K
A
Q
R
Y
L
L
H
G
M
E
C
Chicken
Gallus gallus
NP_001006488
430
49060
Y311
N
N
K
K
A
Q
R
Y
L
L
H
G
F
E
C
Frog
Xenopus laevis
NP_001080311
434
49605
Y309
N
N
K
K
A
Q
R
Y
L
L
H
G
F
E
C
Zebra Danio
Brachydanio rerio
NP_955885
429
49090
Y306
N
N
K
K
A
Q
K
Y
L
L
G
G
F
E
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VXK6
464
51681
Y336
N
N
P
K
A
Q
R
Y
L
I
G
G
V
E
Q
Honey Bee
Apis mellifera
XP_392511
454
50921
Y327
D
D
I
K
A
Q
K
Y
L
I
R
G
I
E
Q
Nematode Worm
Caenorhab. elegans
Q22918
436
48768
Y300
N
D
K
K
A
Q
R
Y
L
L
G
G
V
E
Q
Sea Urchin
Strong. purpuratus
XP_787853
423
47400
Y299
D
N
P
K
G
Q
K
Y
F
L
N
G
L
E
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P55876
451
48894
D334
S
S
T
L
P
P
Q
D
V
M
N
A
P
L
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C8F1
439
48604
F332
D
A
L
F
S
A
L
F
G
G
T
G
K
G
F
Baker's Yeast
Sacchar. cerevisiae
P38431
405
45243
D299
A
Q
C
L
F
D
E
D
I
V
N
E
I
A
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
75.8
93
N.A.
97.2
96.9
N.A.
94.9
92.8
83.4
76
N.A.
50.2
53.2
49.3
52.4
Protein Similarity:
100
99.7
80.1
95.1
N.A.
98.3
98.3
N.A.
97.6
96.7
91.9
89.5
N.A.
68
70.9
65.3
71.2
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
93.3
93.3
93.3
80
N.A.
66.6
46.6
73.3
53.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
93.3
93.3
86.6
N.A.
80
80
86.6
73.3
Percent
Protein Identity:
N.A.
30.3
N.A.
28.7
35.2
N.A.
Protein Similarity:
N.A.
46.7
N.A.
47.3
53.1
N.A.
P-Site Identity:
N.A.
0
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
40
N.A.
26.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
6
0
0
77
6
0
0
0
0
0
6
0
6
0
% A
% Cys:
0
0
6
0
0
0
0
0
0
0
0
0
0
0
59
% C
% Asp:
18
12
0
0
0
6
0
12
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
6
0
0
0
0
6
0
83
12
% E
% Phe:
0
0
0
6
6
0
0
6
6
0
0
0
18
0
6
% F
% Gly:
0
0
0
0
6
0
0
0
6
6
18
89
0
6
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
53
0
0
0
0
% H
% Ile:
0
0
6
0
0
0
0
0
6
12
0
0
12
0
0
% I
% Lys:
0
0
65
83
0
0
18
0
0
0
0
0
6
0
0
% K
% Leu:
0
0
6
12
0
0
6
0
77
71
0
0
42
6
0
% L
% Met:
0
0
0
0
0
0
0
0
0
6
0
0
6
0
0
% M
% Asn:
71
71
0
0
0
0
0
0
0
0
18
0
0
0
0
% N
% Pro:
0
0
12
0
6
6
0
0
0
0
0
0
6
0
0
% P
% Gln:
0
6
0
0
0
83
6
0
0
0
0
0
0
0
24
% Q
% Arg:
0
0
0
0
0
0
65
0
0
0
6
0
0
0
0
% R
% Ser:
6
6
0
0
6
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
6
0
0
0
0
0
0
0
6
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
6
6
0
0
12
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
83
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _