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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF5 All Species: 32.73
Human Site: T153 Identified Species: 45
UniProt: P55010 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.19
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P55010 NP_001960.2 431 49223 T153 P E N S D S G T G K K E K E K
Chimpanzee Pan troglodytes XP_001135628 431 49234 T153 P E N S D S G T G K K E K E K
Rhesus Macaque Macaca mulatta XP_001086107 510 58170 T232 P E N S D S G T G K K E K E K
Dog Lupus familis XP_854659 425 48689 T153 P E N S D S G T G K K E K E K
Cat Felis silvestris
Mouse Mus musculus P59325 429 48950 T153 P E N S D I G T G K K E K E K
Rat Rattus norvegicus Q07205 429 48936 T153 P E N S D I G T G K K E K E K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507766 428 48873 T153 P E N S D S G T G K K E K E K
Chicken Gallus gallus NP_001006488 430 49060 T153 P E S G D T G T G K K E K E K
Frog Xenopus laevis NP_001080311 434 49605 A153 T E N T D G N A G K K E K D K
Zebra Danio Brachydanio rerio NP_955885 429 49090 V153 P E N E S G S V K K E K E K K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VXK6 464 51681 Q154 P S L N P A A Q G S S L T E G
Honey Bee Apis mellifera XP_392511 454 50921 Q154 P S L N P A V Q G S S L T E G
Nematode Worm Caenorhab. elegans Q22918 436 48768 S151 P K I D V D F S K A E Q K N G
Sea Urchin Strong. purpuratus XP_787853 423 47400 P144 T F I I K N P P E H D P R S V
Poplar Tree Populus trichocarpa
Maize Zea mays P55876 451 48894 K154 P E Q K K G G K D K K A M R R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9C8F1 439 48604 K154 P E Q K K S S K D K K S M R R
Baker's Yeast Sacchar. cerevisiae P38431 405 45243 K152 P D S V S G S K K K K K A A T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 75.8 93 N.A. 97.2 96.9 N.A. 94.9 92.8 83.4 76 N.A. 50.2 53.2 49.3 52.4
Protein Similarity: 100 99.7 80.1 95.1 N.A. 98.3 98.3 N.A. 97.6 96.7 91.9 89.5 N.A. 68 70.9 65.3 71.2
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. 100 80 60 33.3 N.A. 20 20 13.3 0
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. 100 93.3 73.3 60 N.A. 33.3 33.3 40 13.3
Percent
Protein Identity: N.A. 30.3 N.A. 28.7 35.2 N.A.
Protein Similarity: N.A. 46.7 N.A. 47.3 53.1 N.A.
P-Site Identity: N.A. 33.3 N.A. 33.3 20 N.A.
P-Site Similarity: N.A. 40 N.A. 40 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 12 6 6 0 6 0 6 6 6 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 6 0 6 53 6 0 0 12 0 6 0 0 6 0 % D
% Glu: 0 71 0 6 0 0 0 0 6 0 12 53 6 59 0 % E
% Phe: 0 6 0 0 0 0 6 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 6 0 24 53 0 65 0 0 0 0 0 18 % G
% His: 0 0 0 0 0 0 0 0 0 6 0 0 0 0 0 % H
% Ile: 0 0 12 6 0 12 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 6 0 12 18 0 0 18 18 77 71 12 59 6 59 % K
% Leu: 0 0 12 0 0 0 0 0 0 0 0 12 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 12 0 0 % M
% Asn: 0 0 53 12 0 6 6 0 0 0 0 0 0 6 0 % N
% Pro: 89 0 0 0 12 0 6 6 0 0 0 6 0 0 0 % P
% Gln: 0 0 12 0 0 0 0 12 0 0 0 6 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 6 12 12 % R
% Ser: 0 12 12 42 12 36 18 6 0 12 12 6 0 6 0 % S
% Thr: 12 0 0 6 0 6 0 48 0 0 0 0 12 0 6 % T
% Val: 0 0 0 6 6 0 6 6 0 0 0 0 0 0 6 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _