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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NAPA All Species: 37.58
Human Site: T286 Identified Species: 55.11
UniProt: P54920 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54920 NP_003818.2 295 33233 T286 M L L R I K K T I Q G D E E D
Chimpanzee Pan troglodytes XP_001169622 285 32181 T276 M L L R I K K T I Q G D E E D
Rhesus Macaque Macaca mulatta XP_001101084 302 33899 S290 M L L R I K K S I Q G D G E G
Dog Lupus familis XP_852154 295 33172 T286 M L L R I K K T I Q G D E E D
Cat Felis silvestris
Mouse Mus musculus Q9DB05 295 33171 T286 M L L R I K K T I Q G D E E D
Rat Rattus norvegicus P54921 295 33174 T286 M L L R I K K T I Q G D E E D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505919 235 26659 Q227 L L E A H E E Q N S E A Y T E
Chicken Gallus gallus XP_419306 296 33307 S286 M L L R I K K S I Q G E G D G
Frog Xenopus laevis NP_001085874 295 33295 T286 M L L R I K K T I Q G E E E D
Zebra Danio Brachydanio rerio NP_956060 295 33225 N286 M L L R I K K N I Q D E E N G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q23983 292 32982 A284 I L L R I K K A A D E D P D L
Honey Bee Apis mellifera XP_625208 292 33268 Q284 V L L R I K K Q V D D N P D L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785670 292 32857 S284 I L L R I K K S I S S D P D L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SPE6 289 32737 K277 M L L R V K E K L K A K E L E
Baker's Yeast Sacchar. cerevisiae P32602 292 32784 S283 I L N K I K E S I Q Q Q E D D
Red Bread Mold Neurospora crassa Q9P6A5 292 32786 N283 V L L Q I K N N F E E A D N E
Conservation
Percent
Protein Identity: 100 96.6 82.1 97.2 N.A. 98.3 98.3 N.A. 68.8 81.7 89.8 84 N.A. 60.6 65.7 N.A. 62.3
Protein Similarity: 100 96.6 92 98.6 N.A. 99.6 99.3 N.A. 75.9 93.5 98.3 93.2 N.A. 79.3 83 N.A. 81
P-Site Identity: 100 100 80 100 N.A. 100 100 N.A. 6.6 66.6 93.3 66.6 N.A. 46.6 40 N.A. 53.3
P-Site Similarity: 100 100 86.6 100 N.A. 100 100 N.A. 33.3 86.6 100 73.3 N.A. 60 66.6 N.A. 73.3
Percent
Protein Identity: N.A. N.A. N.A. 42.3 35.5 34.5
Protein Similarity: N.A. N.A. N.A. 67.1 56.9 56.6
P-Site Identity: N.A. N.A. N.A. 40 46.6 26.6
P-Site Similarity: N.A. N.A. N.A. 73.3 80 60
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 7 0 0 0 7 7 0 7 13 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 13 13 50 7 32 44 % D
% Glu: 0 0 7 0 0 7 19 0 0 7 19 19 57 44 19 % E
% Phe: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 50 0 13 0 19 % G
% His: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 19 0 0 0 88 0 0 0 69 0 0 0 0 0 0 % I
% Lys: 0 0 0 7 0 94 75 7 0 7 0 7 0 0 0 % K
% Leu: 7 100 88 0 0 0 0 0 7 0 0 0 0 7 19 % L
% Met: 63 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 7 0 0 0 7 13 7 0 0 7 0 13 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 19 0 0 % P
% Gln: 0 0 0 7 0 0 0 13 0 63 7 7 0 0 0 % Q
% Arg: 0 0 0 82 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 25 0 13 7 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 38 0 0 0 0 0 7 0 % T
% Val: 13 0 0 0 7 0 0 0 7 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _