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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HIRA All Species: 16.97
Human Site: T554 Identified Species: 23.33
UniProt: P54198 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54198 NP_003316.3 1017 111835 T554 A L S P S V L T T P S K I E P
Chimpanzee Pan troglodytes XP_001165585 1017 111787 T554 A L S P S V L T T P S K I E P
Rhesus Macaque Macaca mulatta XP_001112873 1138 124408 T675 A L S P S V L T T P S K I E P
Dog Lupus familis XP_543550 1017 111618 T554 A S S P S V L T T P S K I E P
Cat Felis silvestris
Mouse Mus musculus Q61666 1015 111748 T554 S S P S V L T T P S K I E P M
Rat Rattus norvegicus NP_001129232 1015 111665 T554 L S P S V L T T P S K I E P M
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P79987 1019 112055 S554 V S T A P P A S S S S V L T T
Frog Xenopus laevis Q8QFR2 1013 112021 Q554 A P T S I T A Q P K I E P M K
Zebra Danio Brachydanio rerio XP_696478 1010 111223 E554 L T S A S K I E P M K A L D S
Tiger Blowfish Takifugu rubipres O42611 1025 111838 I554 L L T S A S K I E P M K A L D
Fruit Fly Dros. melanogaster O17468 1047 113397 V551 C S P S N L N V T A T G K S E
Honey Bee Apis mellifera XP_001122939 838 91355 Q400 K T S V P S T Q T T T L L N T
Nematode Worm Caenorhab. elegans Q09589 935 103412 T497 L S S E G K K T V A P P P A K
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q32SG6 964 105548 G526 S L D Q R M N G T K P S Y G S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LXN4 1051 115544 E554 T A R A T I T E S L V I E K V
Baker's Yeast Sacchar. cerevisiae P32479 840 93871 Q402 P L E K N M E Q L Y R Y G V D
Red Bread Mold Neurospora crassa Q7RZI0 1035 112420 A552 G L P R G G I A A M L L G N K
Conservation
Percent
Protein Identity: 100 99.9 88.4 96.5 N.A. 95.7 95.5 N.A. N.A. 86 78 69.8 67.7 31.1 40 26.5 N.A.
Protein Similarity: 100 99.9 88.9 98 N.A. 97.5 97.7 N.A. N.A. 93.1 88.5 83.2 81.3 48 55.1 46.1 N.A.
P-Site Identity: 100 100 100 93.3 N.A. 6.6 6.6 N.A. N.A. 6.6 6.6 13.3 20 6.6 13.3 13.3 N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 20 13.3 N.A. N.A. 33.3 20 33.3 33.3 26.6 26.6 13.3 N.A.
Percent
Protein Identity: N.A. 25.6 N.A. 25 22.4 25.9
Protein Similarity: N.A. 43.7 N.A. 43.3 41.2 45.8
P-Site Identity: N.A. 13.3 N.A. 0 6.6 6.6
P-Site Similarity: N.A. 26.6 N.A. 26.6 20 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 30 6 0 18 6 0 12 6 6 12 0 6 6 6 0 % A
% Cys: 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 6 0 0 0 0 0 0 0 0 0 0 6 12 % D
% Glu: 0 0 6 6 0 0 6 12 6 0 0 6 18 24 6 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 6 0 0 0 12 6 0 6 0 0 0 6 12 6 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 6 6 12 6 0 0 6 18 24 0 0 % I
% Lys: 6 0 0 6 0 12 12 0 0 12 18 30 6 6 18 % K
% Leu: 24 42 0 0 0 18 24 0 6 6 6 12 18 6 0 % L
% Met: 0 0 0 0 0 12 0 0 0 12 6 0 0 6 12 % M
% Asn: 0 0 0 0 12 0 12 0 0 0 0 0 0 12 0 % N
% Pro: 6 6 24 24 12 6 0 0 24 30 12 6 12 12 24 % P
% Gln: 0 0 0 6 0 0 0 18 0 0 0 0 0 0 0 % Q
% Arg: 0 0 6 6 6 0 0 0 0 0 6 0 0 0 0 % R
% Ser: 12 36 42 30 30 12 0 6 12 18 30 6 0 6 12 % S
% Thr: 6 12 18 0 6 6 24 42 42 6 12 0 0 6 12 % T
% Val: 6 0 0 6 12 24 0 6 6 0 6 6 0 6 6 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 6 0 6 6 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _