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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HIRA All Species: 15.76
Human Site: S551 Identified Species: 21.67
UniProt: P54198 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54198 NP_003316.3 1017 111835 S551 T P A A L S P S V L T T P S K
Chimpanzee Pan troglodytes XP_001165585 1017 111787 S551 T P A A L S P S V L T T P S K
Rhesus Macaque Macaca mulatta XP_001112873 1138 124408 S672 T P A A L S P S V L T T P S K
Dog Lupus familis XP_543550 1017 111618 S551 T P A A S S P S V L T T P S K
Cat Felis silvestris
Mouse Mus musculus Q61666 1015 111748 V551 P A A S S P S V L T T P S K I
Rat Rattus norvegicus NP_001129232 1015 111665 V551 P A A L S P S V L T T P S K I
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P79987 1019 112055 P551 A T S V S T A P P A S S S S V
Frog Xenopus laevis Q8QFR2 1013 112021 I551 S P V A P T S I T A Q P K I E
Zebra Danio Brachydanio rerio XP_696478 1010 111223 S551 T L L L T S A S K I E P M K A
Tiger Blowfish Takifugu rubipres O42611 1025 111838 A551 S C L L L T S A S K I E P M K
Fruit Fly Dros. melanogaster O17468 1047 113397 N548 S S T C S P S N L N V T A T G
Honey Bee Apis mellifera XP_001122939 838 91355 P397 L N L K T S V P S T Q T T T L
Nematode Worm Caenorhab. elegans Q09589 935 103412 G494 M T S L S S E G K K T V A P P
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q32SG6 964 105548 R523 N F S S L D Q R M N G T K P S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LXN4 1051 115544 T551 S R I T A R A T I T E S L V I
Baker's Yeast Sacchar. cerevisiae P32479 840 93871 N399 K P I P L E K N M E Q L Y R Y
Red Bread Mold Neurospora crassa Q7RZI0 1035 112420 G549 P Y D G L P R G G I A A M L L
Conservation
Percent
Protein Identity: 100 99.9 88.4 96.5 N.A. 95.7 95.5 N.A. N.A. 86 78 69.8 67.7 31.1 40 26.5 N.A.
Protein Similarity: 100 99.9 88.9 98 N.A. 97.5 97.7 N.A. N.A. 93.1 88.5 83.2 81.3 48 55.1 46.1 N.A.
P-Site Identity: 100 100 100 93.3 N.A. 13.3 13.3 N.A. N.A. 6.6 13.3 20 20 6.6 13.3 13.3 N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 26.6 20 N.A. N.A. 33.3 33.3 26.6 40 33.3 20 20 N.A.
Percent
Protein Identity: N.A. 25.6 N.A. 25 22.4 25.9
Protein Similarity: N.A. 43.7 N.A. 43.3 41.2 45.8
P-Site Identity: N.A. 13.3 N.A. 0 13.3 6.6
P-Site Similarity: N.A. 33.3 N.A. 26.6 26.6 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 12 36 30 6 0 18 6 0 12 6 6 12 0 6 % A
% Cys: 0 6 0 6 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 6 0 0 6 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 6 6 0 0 6 12 6 0 0 6 % E
% Phe: 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 6 0 0 0 12 6 0 6 0 0 0 6 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 12 0 0 0 0 6 6 12 6 0 0 6 18 % I
% Lys: 6 0 0 6 0 0 6 0 12 12 0 0 12 18 30 % K
% Leu: 6 6 18 24 42 0 0 0 18 24 0 6 6 6 12 % L
% Met: 6 0 0 0 0 0 0 0 12 0 0 0 12 6 0 % M
% Asn: 6 6 0 0 0 0 0 12 0 12 0 0 0 0 0 % N
% Pro: 18 36 0 6 6 24 24 12 6 0 0 24 30 12 6 % P
% Gln: 0 0 0 0 0 0 6 0 0 0 18 0 0 0 0 % Q
% Arg: 0 6 0 0 0 6 6 6 0 0 0 0 0 6 0 % R
% Ser: 24 6 18 12 36 42 30 30 12 0 6 12 18 30 6 % S
% Thr: 30 12 6 6 12 18 0 6 6 24 42 42 6 12 0 % T
% Val: 0 0 6 6 0 0 6 12 24 0 6 6 0 6 6 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 6 0 0 0 0 0 0 0 0 0 0 6 0 6 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _