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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSC
All Species:
32.73
Human Site:
T391
Identified Species:
55.38
UniProt:
P53634
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.31
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53634
NP_001805.3
463
51842
T391
K
K
G
I
Y
H
H
T
G
L
R
D
P
F
N
Chimpanzee
Pan troglodytes
XP_508684
463
51907
T391
K
K
G
I
Y
H
H
T
G
L
R
D
P
F
N
Rhesus Macaque
Macaca mulatta
XP_001104734
463
51874
T391
Q
N
G
I
Y
H
H
T
G
L
R
D
P
F
N
Dog
Lupus familis
XP_535784
481
54085
T409
Q
K
G
I
Y
Y
H
T
G
L
R
D
P
I
N
Cat
Felis silvestris
Mouse
Mus musculus
P97821
462
52358
T390
H
S
G
I
Y
H
H
T
G
L
S
D
P
F
N
Rat
Rattus norvegicus
P80067
462
52217
T390
H
S
G
I
Y
H
H
T
G
L
S
D
P
F
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512140
469
52438
T397
R
E
G
V
Y
H
H
T
G
L
R
D
P
F
N
Chicken
Gallus gallus
P43233
340
37569
Q269
M
Y
K
S
G
V
Y
Q
H
V
S
G
E
Q
V
Frog
Xenopus laevis
NP_001080511
458
51565
T386
R
S
G
V
Y
H
H
T
G
L
Q
D
K
F
N
Zebra Danio
Brachydanio rerio
NP_999887
455
50596
T383
K
E
G
I
Y
H
H
T
G
L
R
D
A
N
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P43510
379
42386
K308
L
G
G
G
H
A
V
K
L
I
G
W
G
I
D
Sea Urchin
Strong. purpuratus
XP_001201161
459
51309
K388
I
Y
H
H
T
G
V
K
N
E
N
L
K
F
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q10717
360
39181
K289
I
T
G
F
R
L
Y
K
S
G
V
Y
T
S
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H166
358
38941
K287
I
H
S
F
R
L
Y
K
S
G
V
Y
T
D
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
95.6
79
N.A.
77.7
78.6
N.A.
72
22.8
62.4
63.2
N.A.
N.A.
N.A.
23.3
54.8
Protein Similarity:
100
99.7
97.4
85.4
N.A.
86.6
87
N.A.
83.5
38
77.3
77.1
N.A.
N.A.
N.A.
38.2
71.4
P-Site Identity:
100
100
86.6
80
N.A.
80
80
N.A.
80
0
66.6
80
N.A.
N.A.
N.A.
6.6
13.3
P-Site Similarity:
100
100
93.3
93.3
N.A.
80
80
N.A.
100
13.3
86.6
86.6
N.A.
N.A.
N.A.
26.6
13.3
Percent
Protein Identity:
N.A.
27.8
N.A.
27
N.A.
N.A.
Protein Similarity:
N.A.
42.5
N.A.
43.2
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
20
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
0
0
0
0
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
65
0
8
15
% D
% Glu:
0
15
0
0
0
0
0
0
0
8
0
0
8
0
0
% E
% Phe:
0
0
0
15
0
0
0
0
0
0
0
0
0
58
0
% F
% Gly:
0
8
79
8
8
8
0
0
65
15
8
8
8
0
0
% G
% His:
15
8
8
8
8
58
65
0
8
0
0
0
0
0
0
% H
% Ile:
22
0
0
50
0
0
0
0
0
8
0
0
0
15
0
% I
% Lys:
22
22
8
0
0
0
0
29
0
0
0
0
15
0
0
% K
% Leu:
8
0
0
0
0
15
0
0
8
65
0
8
0
0
0
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
0
0
8
0
8
0
0
8
72
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
50
0
0
% P
% Gln:
15
0
0
0
0
0
0
8
0
0
8
0
0
8
0
% Q
% Arg:
15
0
0
0
15
0
0
0
0
0
43
0
0
0
0
% R
% Ser:
0
22
8
8
0
0
0
0
15
0
22
0
0
8
8
% S
% Thr:
0
8
0
0
8
0
0
65
0
0
0
0
15
0
0
% T
% Val:
0
0
0
15
0
8
15
0
0
8
15
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
0
15
0
0
65
8
22
0
0
0
0
15
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _