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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSC
All Species:
15.45
Human Site:
T221
Identified Species:
26.15
UniProt:
P53634
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53634
NP_001805.3
463
51842
T221
R
P
K
P
A
P
L
T
A
E
I
Q
Q
K
I
Chimpanzee
Pan troglodytes
XP_508684
463
51907
T221
R
P
K
P
A
P
L
T
A
E
I
Q
Q
K
L
Rhesus Macaque
Macaca mulatta
XP_001104734
463
51874
T221
R
P
K
P
A
P
L
T
A
E
I
Q
Q
K
I
Dog
Lupus familis
XP_535784
481
54085
E242
K
P
T
P
L
T
A
E
I
H
E
E
I
S
R
Cat
Felis silvestris
Mouse
Mus musculus
P97821
462
52358
D221
P
K
P
A
P
M
T
D
E
I
Q
Q
Q
I
L
Rat
Rattus norvegicus
P80067
462
52217
D221
P
K
P
A
P
I
T
D
E
I
Q
Q
Q
I
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512140
469
52438
S227
R
P
K
P
A
P
L
S
P
E
L
A
N
Q
A
Chicken
Gallus gallus
P43233
340
37569
W109
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
Frog
Xenopus laevis
NP_001080511
458
51565
K222
A
P
M
P
T
D
Q
K
Y
Q
G
L
P
N
E
Zebra Danio
Brachydanio rerio
NP_999887
455
50596
S222
A
A
D
S
K
A
A
S
G
L
P
Q
H
W
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P43510
379
42386
I148
A
M
S
D
R
I
C
I
A
S
H
G
E
L
Q
Sea Urchin
Strong. purpuratus
XP_001201161
459
51309
P224
K
R
A
A
S
S
L
P
P
G
F
D
W
R
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q10717
360
39181
T129
A
A
Q
N
C
S
A
T
L
T
G
N
H
R
M
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H166
358
38941
S127
L
G
A
A
Q
N
C
S
A
T
L
K
G
S
H
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
95.6
79
N.A.
77.7
78.6
N.A.
72
22.8
62.4
63.2
N.A.
N.A.
N.A.
23.3
54.8
Protein Similarity:
100
99.7
97.4
85.4
N.A.
86.6
87
N.A.
83.5
38
77.3
77.1
N.A.
N.A.
N.A.
38.2
71.4
P-Site Identity:
100
93.3
100
13.3
N.A.
13.3
13.3
N.A.
53.3
6.6
13.3
6.6
N.A.
N.A.
N.A.
6.6
6.6
P-Site Similarity:
100
100
100
26.6
N.A.
20
20
N.A.
73.3
20
20
13.3
N.A.
N.A.
N.A.
13.3
26.6
Percent
Protein Identity:
N.A.
27.8
N.A.
27
N.A.
N.A.
Protein Similarity:
N.A.
42.5
N.A.
43.2
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
29
15
15
29
29
8
22
0
43
0
0
15
0
0
15
% A
% Cys:
0
0
0
8
8
0
22
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
8
0
8
0
15
0
0
0
8
0
0
8
% D
% Glu:
0
0
0
0
0
0
0
8
15
29
8
8
8
8
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% F
% Gly:
0
15
0
0
8
0
0
0
8
8
22
8
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
8
0
15
0
8
% H
% Ile:
0
0
0
0
0
15
0
8
8
15
22
0
8
15
15
% I
% Lys:
15
15
29
0
8
0
0
8
0
0
0
8
0
22
0
% K
% Leu:
8
0
0
0
8
0
36
0
8
8
15
8
0
8
22
% L
% Met:
0
8
8
0
0
8
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
8
0
8
0
0
0
0
0
8
8
8
8
% N
% Pro:
15
43
15
43
15
29
0
8
15
0
8
0
8
0
0
% P
% Gln:
8
0
8
0
8
0
8
0
0
8
15
43
36
8
8
% Q
% Arg:
29
8
0
0
8
0
0
0
0
0
0
0
0
15
8
% R
% Ser:
0
0
15
8
8
22
0
22
0
8
0
0
0
15
0
% S
% Thr:
0
0
8
0
8
8
15
29
0
15
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
0
0
8
8
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _