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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CTSC All Species: 16.06
Human Site: S284 Identified Species: 27.18
UniProt: P53634 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P53634 NP_001805.3 463 51842 S284 N S Q T P I L S P Q E V V S C
Chimpanzee Pan troglodytes XP_508684 463 51907 S284 N S Q T P I L S P Q E V V S C
Rhesus Macaque Macaca mulatta XP_001104734 463 51874 S284 N S Q T P I L S P Q E V V S C
Dog Lupus familis XP_535784 481 54085 Q305 Q T P I L S P Q E I V S C S Q
Cat Felis silvestris
Mouse Mus musculus P97821 462 52358 P284 S Q T P I L S P Q E V V S C S
Rat Rattus norvegicus P80067 462 52217 P284 S Q T P I L S P Q E V V S C S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512140 469 52438 S290 N S Q T P I L S T Q Q I V S C
Chicken Gallus gallus P43233 340 37569 L172 R G L V S G G L Y D S H V G C
Frog Xenopus laevis NP_001080511 458 51565 S285 L S P Q Q V V S C S N Y S Q G
Zebra Danio Brachydanio rerio NP_999887 455 50596 S285 P Q Q V V S C S Q Y S Q G C D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P43510 379 42386 C211 K P Y P F P P C E H H S K K T
Sea Urchin Strong. purpuratus XP_001201161 459 51309 Y287 D V V S C S E Y S Q G C E G G
Poplar Tree Populus trichocarpa
Maize Zea mays Q10717 360 39181 E192 G K P I S L S E Q Q L V D C G
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8H166 358 38941 E190 G K G I S L S E Q Q L V D C A
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 95.6 79 N.A. 77.7 78.6 N.A. 72 22.8 62.4 63.2 N.A. N.A. N.A. 23.3 54.8
Protein Similarity: 100 99.7 97.4 85.4 N.A. 86.6 87 N.A. 83.5 38 77.3 77.1 N.A. N.A. N.A. 38.2 71.4
P-Site Identity: 100 100 100 6.6 N.A. 6.6 6.6 N.A. 80 13.3 13.3 13.3 N.A. N.A. N.A. 0 6.6
P-Site Similarity: 100 100 100 13.3 N.A. 26.6 26.6 N.A. 93.3 13.3 26.6 13.3 N.A. N.A. N.A. 0 20
Percent
Protein Identity: N.A. 27.8 N.A. 27 N.A. N.A.
Protein Similarity: N.A. 42.5 N.A. 43.2 N.A. N.A.
P-Site Identity: N.A. 13.3 N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. 20 N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % A
% Cys: 0 0 0 0 8 0 8 8 8 0 0 8 8 36 36 % C
% Asp: 8 0 0 0 0 0 0 0 0 8 0 0 15 0 8 % D
% Glu: 0 0 0 0 0 0 8 15 15 15 22 0 8 0 0 % E
% Phe: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 15 8 8 0 0 8 8 0 0 0 8 0 8 15 22 % G
% His: 0 0 0 0 0 0 0 0 0 8 8 8 0 0 0 % H
% Ile: 0 0 0 22 15 29 0 0 0 8 0 8 0 0 0 % I
% Lys: 8 15 0 0 0 0 0 0 0 0 0 0 8 8 0 % K
% Leu: 8 0 8 0 8 29 29 8 0 0 15 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 29 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % N
% Pro: 8 8 22 22 29 8 15 15 22 0 0 0 0 0 0 % P
% Gln: 8 22 36 8 8 0 0 8 36 50 8 8 0 8 8 % Q
% Arg: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 15 36 0 8 22 22 29 43 8 8 15 15 22 36 15 % S
% Thr: 0 8 15 29 0 0 0 0 8 0 0 0 0 0 8 % T
% Val: 0 8 8 15 8 8 8 0 0 0 22 50 36 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 0 0 8 8 8 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _