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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CTSC All Species: 15.45
Human Site: S278 Identified Species: 26.15
UniProt: P53634 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P53634 NP_001805.3 463 51842 S278 I R I L T N N S Q T P I L S P
Chimpanzee Pan troglodytes XP_508684 463 51907 S278 I R I L T N N S Q T P I L S P
Rhesus Macaque Macaca mulatta XP_001104734 463 51874 S278 I R I L T N N S Q T P I L S P
Dog Lupus familis XP_535784 481 54085 T299 I L T N N T Q T P I L S P Q E
Cat Felis silvestris
Mouse Mus musculus P97821 462 52358 Q278 R I L T N N S Q T P I L S P Q
Rat Rattus norvegicus P80067 462 52217 Q278 R I L T N N S Q T P I L S P Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512140 469 52438 S284 I R I L T N N S Q T P I L S T
Chicken Gallus gallus P43233 340 37569 G166 W R Y W T E R G L V S G G L Y
Frog Xenopus laevis NP_001080511 458 51565 S279 L S Q K P I L S P Q Q V V S C
Zebra Danio Brachydanio rerio NP_999887 455 50596 Q279 Q Q P V F S P Q Q V V S C S Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P43510 379 42386 P205 T A N N G C K P Y P F P P C E
Sea Urchin Strong. purpuratus XP_001201161 459 51309 V281 L V F S T Q D V V S C S E Y S
Poplar Tree Populus trichocarpa
Maize Zea mays Q10717 360 39181 K186 A Y T Q A T G K P I S L S E Q
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8H166 358 38941 K184 A Y H Q A F G K G I S L S E Q
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 95.6 79 N.A. 77.7 78.6 N.A. 72 22.8 62.4 63.2 N.A. N.A. N.A. 23.3 54.8
Protein Similarity: 100 99.7 97.4 85.4 N.A. 86.6 87 N.A. 83.5 38 77.3 77.1 N.A. N.A. N.A. 38.2 71.4
P-Site Identity: 100 100 100 6.6 N.A. 6.6 6.6 N.A. 93.3 13.3 13.3 13.3 N.A. N.A. N.A. 0 6.6
P-Site Similarity: 100 100 100 13.3 N.A. 26.6 26.6 N.A. 93.3 13.3 33.3 33.3 N.A. N.A. N.A. 0 26.6
Percent
Protein Identity: N.A. 27.8 N.A. 27 N.A. N.A.
Protein Similarity: N.A. 42.5 N.A. 43.2 N.A. N.A.
P-Site Identity: N.A. 0 N.A. 0 N.A. N.A.
P-Site Similarity: N.A. 6.6 N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 15 8 0 0 15 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 8 0 0 0 0 8 0 8 8 8 % C
% Asp: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 8 0 0 0 0 0 0 8 15 15 % E
% Phe: 0 0 8 0 8 8 0 0 0 0 8 0 0 0 0 % F
% Gly: 0 0 0 0 8 0 15 8 8 0 0 8 8 0 0 % G
% His: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 36 15 29 0 0 8 0 0 0 22 15 29 0 0 0 % I
% Lys: 0 0 0 8 0 0 8 15 0 0 0 0 0 0 0 % K
% Leu: 15 8 15 29 0 0 8 0 8 0 8 29 29 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 15 22 43 29 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 8 0 8 0 8 8 22 22 29 8 15 15 22 % P
% Gln: 8 8 8 15 0 8 8 22 36 8 8 0 0 8 36 % Q
% Arg: 15 36 0 0 0 0 8 0 0 0 0 0 0 0 0 % R
% Ser: 0 8 0 8 0 8 15 36 0 8 22 22 29 43 8 % S
% Thr: 8 0 15 15 43 15 0 8 15 29 0 0 0 0 8 % T
% Val: 0 8 0 8 0 0 0 8 8 15 8 8 8 0 0 % V
% Trp: 8 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 15 8 0 0 0 0 0 8 0 0 0 0 8 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _