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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CTSC All Species: 15.15
Human Site: S146 Identified Species: 25.64
UniProt: P53634 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P53634 NP_001805.3 463 51842 S146 G K K V G T A S E N V Y V N T
Chimpanzee Pan troglodytes XP_508684 463 51907 S146 G K K V G T A S E N V Y V N T
Rhesus Macaque Macaca mulatta XP_001104734 463 51874 S146 G K K V G T A S E N V Y V N T
Dog Lupus familis XP_535784 481 54085 S167 G T K M G T T S E K A K V N T
Cat Felis silvestris
Mouse Mus musculus P97821 462 52358 I146 G K K V E S H I E K V N M N A
Rat Rattus norvegicus P80067 462 52217 S146 G K K M A N H S E K V Y V N V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512140 469 52438 L152 K I S S A S P L G G V Y V N Q
Chicken Gallus gallus P43233 340 37569 I34 S S D L V N H I N K L N T T G
Frog Xenopus laevis NP_001080511 458 51565 R147 V S A E S G V R V N P D P F P
Zebra Danio Brachydanio rerio NP_999887 455 50596 H147 P P R V D R R H M L G F E H R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P43510 379 42386 D73 S S V Y G E N D K A K W G L M
Sea Urchin Strong. purpuratus XP_001201161 459 51309 V149 K V H T N A K V K R L K S F K
Poplar Tree Populus trichocarpa
Maize Zea mays Q10717 360 39181 R54 F A A L G R T R D A L R F A R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8H166 358 38941 Q52 S V S Q I L G Q S R H V L S F
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 95.6 79 N.A. 77.7 78.6 N.A. 72 22.8 62.4 63.2 N.A. N.A. N.A. 23.3 54.8
Protein Similarity: 100 99.7 97.4 85.4 N.A. 86.6 87 N.A. 83.5 38 77.3 77.1 N.A. N.A. N.A. 38.2 71.4
P-Site Identity: 100 100 100 60 N.A. 46.6 60 N.A. 26.6 0 6.6 6.6 N.A. N.A. N.A. 6.6 0
P-Site Similarity: 100 100 100 66.6 N.A. 60 66.6 N.A. 33.3 13.3 6.6 26.6 N.A. N.A. N.A. 20 13.3
Percent
Protein Identity: N.A. 27.8 N.A. 27 N.A. N.A.
Protein Similarity: N.A. 42.5 N.A. 43.2 N.A. N.A.
P-Site Identity: N.A. 6.6 N.A. 0 N.A. N.A.
P-Site Similarity: N.A. 26.6 N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 15 0 15 8 22 0 0 15 8 0 0 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 0 8 0 0 8 8 0 0 8 0 0 0 % D
% Glu: 0 0 0 8 8 8 0 0 43 0 0 0 8 0 0 % E
% Phe: 8 0 0 0 0 0 0 0 0 0 0 8 8 15 8 % F
% Gly: 43 0 0 0 43 8 8 0 8 8 8 0 8 0 8 % G
% His: 0 0 8 0 0 0 22 8 0 0 8 0 0 8 0 % H
% Ile: 0 8 0 0 8 0 0 15 0 0 0 0 0 0 0 % I
% Lys: 15 36 43 0 0 0 8 0 15 29 8 15 0 0 8 % K
% Leu: 0 0 0 15 0 8 0 8 0 8 22 0 8 8 0 % L
% Met: 0 0 0 15 0 0 0 0 8 0 0 0 8 0 8 % M
% Asn: 0 0 0 0 8 15 8 0 8 29 0 15 0 50 0 % N
% Pro: 8 8 0 0 0 0 8 0 0 0 8 0 8 0 8 % P
% Gln: 0 0 0 8 0 0 0 8 0 0 0 0 0 0 8 % Q
% Arg: 0 0 8 0 0 15 8 15 0 15 0 8 0 0 15 % R
% Ser: 22 22 15 8 8 15 0 36 8 0 0 0 8 8 0 % S
% Thr: 0 8 0 8 0 29 15 0 0 0 0 0 8 8 29 % T
% Val: 8 15 8 36 8 0 8 8 8 0 43 8 43 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 0 0 0 0 36 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _