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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-5
All Species:
20.61
Human Site:
Y253
Identified Species:
41.21
UniProt:
P52952
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52952
NP_004378.1
324
34918
Y253
N
P
Y
G
Y
N
A
Y
P
A
Y
P
G
Y
G
Chimpanzee
Pan troglodytes
XP_518104
325
35024
Y254
N
P
Y
G
Y
N
A
Y
P
A
Y
P
G
Y
G
Rhesus Macaque
Macaca mulatta
XP_001096796
324
34944
Y253
N
A
Y
G
Y
N
A
Y
P
A
Y
P
C
Y
G
Dog
Lupus familis
XP_543239
342
36276
G276
P
A
F
P
G
P
Y
G
A
P
A
A
P
Y
S
Cat
Felis silvestris
Mouse
Mus musculus
P42582
318
34144
Y249
N
A
Y
G
Y
N
A
Y
P
Y
P
S
Y
G
G
Rat
Rattus norvegicus
O35767
318
34318
Y249
N
A
Y
G
Y
N
A
Y
P
Y
P
G
Y
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
Y229
N
P
Y
S
Y
N
A
Y
P
A
Y
P
N
Y
N
Frog
Xenopus laevis
P42583
299
34079
Y234
N
P
Y
S
Y
N
T
Y
P
A
Y
S
N
Y
S
Zebra Danio
Brachydanio rerio
Q90481
269
30288
V204
P
R
R
V
A
V
P
V
L
V
R
D
G
K
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001015473
468
50968
G369
T
S
A
G
N
N
T
G
S
A
N
N
G
N
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
D222
S
G
L
G
H
S
E
D
G
S
S
P
P
P
D
Sea Urchin
Strong. purpuratus
XP_783123
344
37966
A257
G
T
A
T
A
V
A
A
A
A
A
A
A
R
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.8
40
N.A.
87.6
85.8
N.A.
N.A.
66.6
62.3
32.4
N.A.
26.9
N.A.
29.3
35.1
Protein Similarity:
100
99.3
97.8
49.7
N.A.
91.3
89.5
N.A.
N.A.
76.8
73.7
43.8
N.A.
40.5
N.A.
42.2
49.7
P-Site Identity:
100
100
86.6
6.6
N.A.
60
60
N.A.
N.A.
80
66.6
6.6
N.A.
26.6
N.A.
13.3
13.3
P-Site Similarity:
100
100
86.6
13.3
N.A.
60
60
N.A.
N.A.
80
66.6
6.6
N.A.
26.6
N.A.
40
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
34
17
0
17
0
59
9
17
59
17
17
9
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% C
% Asp:
0
0
0
0
0
0
0
9
0
0
0
9
0
0
9
% D
% Glu:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
9
0
59
9
0
0
17
9
0
0
9
34
17
42
% G
% His:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
9
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% K
% Leu:
0
0
9
0
0
0
0
0
9
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
59
0
0
0
9
67
0
0
0
0
9
9
17
9
9
% N
% Pro:
17
34
0
9
0
9
9
0
59
9
17
42
17
9
9
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
9
9
0
0
0
0
0
0
0
9
0
0
9
0
% R
% Ser:
9
9
0
17
0
9
0
0
9
9
9
17
0
0
17
% S
% Thr:
9
9
0
9
0
0
17
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
9
0
17
0
9
0
9
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
59
0
59
0
9
59
0
17
42
0
17
50
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _