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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-5
All Species:
6.67
Human Site:
T125
Identified Species:
13.33
UniProt:
P52952
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52952
NP_004378.1
324
34918
T125
K
A
V
E
L
E
K
T
E
A
D
N
A
E
R
Chimpanzee
Pan troglodytes
XP_518104
325
35024
T125
K
A
V
E
L
E
K
T
E
V
D
N
A
E
R
Rhesus Macaque
Macaca mulatta
XP_001096796
324
34944
P125
K
V
V
E
L
E
K
P
E
A
D
N
A
E
R
Dog
Lupus familis
XP_543239
342
36276
A115
N
H
L
D
L
K
D
A
P
R
E
G
L
Q
Q
Cat
Felis silvestris
Mouse
Mus musculus
P42582
318
34144
A124
K
A
V
E
L
D
K
A
E
T
D
G
A
E
R
Rat
Rattus norvegicus
O35767
318
34318
A124
K
A
V
E
L
D
K
A
E
T
D
G
A
E
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
R106
K
S
L
E
Q
E
K
R
E
L
E
D
P
E
R
Frog
Xenopus laevis
P42583
299
34079
R111
K
T
L
E
H
D
K
R
E
A
E
D
P
E
R
Zebra Danio
Brachydanio rerio
Q90481
269
30288
S100
S
Q
D
T
S
A
K
S
P
E
P
S
A
D
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001015473
468
50968
L246
S
V
S
D
S
K
P
L
Q
F
P
L
A
Q
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
Y113
S
G
A
Q
P
N
W
Y
N
G
N
D
P
R
F
Sea Urchin
Strong. purpuratus
XP_783123
344
37966
G140
T
A
P
N
T
N
P
G
N
T
L
Q
S
A
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.8
40
N.A.
87.6
85.8
N.A.
N.A.
66.6
62.3
32.4
N.A.
26.9
N.A.
29.3
35.1
Protein Similarity:
100
99.3
97.8
49.7
N.A.
91.3
89.5
N.A.
N.A.
76.8
73.7
43.8
N.A.
40.5
N.A.
42.2
49.7
P-Site Identity:
100
93.3
86.6
6.6
N.A.
73.3
73.3
N.A.
N.A.
46.6
46.6
13.3
N.A.
13.3
N.A.
0
6.6
P-Site Similarity:
100
93.3
86.6
46.6
N.A.
80
80
N.A.
N.A.
73.3
73.3
33.3
N.A.
40
N.A.
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
42
9
0
0
9
0
25
0
25
0
0
59
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
17
0
25
9
0
0
0
42
25
0
9
9
% D
% Glu:
0
0
0
59
0
34
0
0
59
9
25
0
0
59
9
% E
% Phe:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
9
% F
% Gly:
0
9
0
0
0
0
0
9
0
9
0
25
0
0
0
% G
% His:
0
9
0
0
9
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
59
0
0
0
0
17
67
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
25
0
50
0
0
9
0
9
9
9
9
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
9
0
0
9
0
17
0
0
17
0
9
25
0
0
0
% N
% Pro:
0
0
9
0
9
0
17
9
17
0
17
0
25
0
0
% P
% Gln:
0
9
0
9
9
0
0
0
9
0
0
9
0
17
9
% Q
% Arg:
0
0
0
0
0
0
0
17
0
9
0
0
0
9
67
% R
% Ser:
25
9
9
0
17
0
0
9
0
0
0
9
9
0
0
% S
% Thr:
9
9
0
9
9
0
0
17
0
25
0
0
0
0
0
% T
% Val:
0
17
42
0
0
0
0
0
0
9
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _