Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MSH6 All Species: 6.97
Human Site: T363 Identified Species: 10.95
UniProt: P52701 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P52701 NP_000170.1 1360 152786 T363 G D D S S R P T V W Y H E T L
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001113749 1360 152750 T363 G D D S S R P T V W Y H E T L
Dog Lupus familis XP_531814 1283 145094 I346 K S Q N F D L I I F Y K V G K
Cat Felis silvestris
Mouse Mus musculus P54276 1358 151058 V363 N D S S G P T V W Y H E T L E
Rat Rattus norvegicus XP_002726765 1361 151628 I366 N D S S G P T I W Y H E T L E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_419359 1466 164165 T467 A N A C S G G T N G F A A W E
Frog Xenopus laevis NP_001089247 1340 149481 H346 G A V S I W E H E K F D W L Q
Zebra Danio Brachydanio rerio NP_878280 1369 153213 D365 E G G S T V W D H E K L E W L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VUM0 1190 133117 W268 L S P G V R Q W W V L K S D N
Honey Bee Apis mellifera XP_392346 1120 127429 K198 N K I R D I N K K S P N D S D
Nematode Worm Caenorhab. elegans NP_491163 1186 133609 H264 W W T M K S Q H F D T I L L F
Sea Urchin Strong. purpuratus XP_797647 1335 149141 T345 P S K K T F G T P S A Q S S M
Poplar Tree Populus trichocarpa XP_002320307 1288 142120 L353 A H V G A K E L D L Q Y M K G
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O04716 1324 146779 F346 R D S E K F R F L G V D R R D
Baker's Yeast Sacchar. cerevisiae Q03834 1242 140062 E320 P F E K Q Y W E I K S K M W D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 98.3 88.1 N.A. 85.8 86.4 N.A. N.A. 64.2 66.5 60 N.A. 39 41.2 34.4 48.6
Protein Similarity: 100 N.A. 98.6 91.3 N.A. 92.1 92.8 N.A. N.A. 75.4 79.9 74.9 N.A. 57.6 58 52.7 66.6
P-Site Identity: 100 N.A. 100 6.6 N.A. 13.3 13.3 N.A. N.A. 13.3 13.3 20 N.A. 6.6 0 0 6.6
P-Site Similarity: 100 N.A. 100 26.6 N.A. 26.6 26.6 N.A. N.A. 26.6 20 26.6 N.A. 6.6 20 0 26.6
Percent
Protein Identity: 36.1 N.A. N.A. 33.2 29 N.A.
Protein Similarity: 52 N.A. N.A. 51.4 49.1 N.A.
P-Site Identity: 0 N.A. N.A. 6.6 0 N.A.
P-Site Similarity: 20 N.A. N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 7 7 0 7 0 0 0 0 0 7 7 7 0 0 % A
% Cys: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 34 14 0 7 7 0 7 7 7 0 14 7 7 20 % D
% Glu: 7 0 7 7 0 0 14 7 7 7 0 14 20 0 20 % E
% Phe: 0 7 0 0 7 14 0 7 7 7 14 0 0 0 7 % F
% Gly: 20 7 7 14 14 7 14 0 0 14 0 0 0 7 7 % G
% His: 0 7 0 0 0 0 0 14 7 0 14 14 0 0 0 % H
% Ile: 0 0 7 0 7 7 0 14 14 0 0 7 0 0 0 % I
% Lys: 7 7 7 14 14 7 0 7 7 14 7 20 0 7 7 % K
% Leu: 7 0 0 0 0 0 7 7 7 7 7 7 7 27 20 % L
% Met: 0 0 0 7 0 0 0 0 0 0 0 0 14 0 7 % M
% Asn: 20 7 0 7 0 0 7 0 7 0 0 7 0 0 7 % N
% Pro: 14 0 7 0 0 14 14 0 7 0 7 0 0 0 0 % P
% Gln: 0 0 7 0 7 0 14 0 0 0 7 7 0 0 7 % Q
% Arg: 7 0 0 7 0 20 7 0 0 0 0 0 7 7 0 % R
% Ser: 0 20 20 40 20 7 0 0 0 14 7 0 14 14 0 % S
% Thr: 0 0 7 0 14 0 14 27 0 0 7 0 14 14 0 % T
% Val: 0 0 14 0 7 7 0 7 14 7 7 0 7 0 0 % V
% Trp: 7 7 0 0 0 7 14 7 20 14 0 0 7 20 0 % W
% Tyr: 0 0 0 0 0 7 0 0 0 14 20 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _