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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
18.18
Human Site:
S285
Identified Species:
28.57
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
S285
I
S
S
G
V
G
D
S
E
S
E
G
L
N
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
S285
I
S
S
G
V
G
D
S
E
S
E
G
P
N
S
Dog
Lupus familis
XP_531814
1283
145094
S268
A
Y
S
A
P
Q
N
S
E
S
Q
A
H
I
G
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
S285
A
S
S
G
V
G
D
S
D
S
E
D
L
G
T
Rat
Rattus norvegicus
XP_002726765
1361
151628
S288
V
S
S
G
V
G
D
S
D
S
E
G
L
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
E389
S
S
G
V
D
E
N
E
A
T
D
V
E
T
D
Frog
Xenopus laevis
NP_001089247
1340
149481
D268
E
A
G
L
S
E
P
D
S
E
A
E
D
N
S
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
E287
V
N
S
G
A
E
E
E
E
S
E
P
E
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
K190
E
G
A
T
F
Q
E
K
L
K
N
L
Q
S
N
Honey Bee
Apis mellifera
XP_392346
1120
127429
S120
D
S
V
S
E
G
V
S
E
S
E
P
P
T
A
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
R186
I
M
D
G
E
G
E
R
K
R
I
V
E
K
T
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
S267
I
S
A
S
E
T
E
S
D
P
E
T
P
K
K
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
P275
V
R
V
S
V
V
E
P
V
K
H
K
E
S
K
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
R268
E
E
T
S
K
V
N
R
V
S
K
T
D
S
R
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
K242
S
R
D
N
S
K
K
K
S
R
P
N
Q
A
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
93.3
26.6
N.A.
66.6
80
N.A.
N.A.
6.6
13.3
33.3
N.A.
0
40
20
26.6
P-Site Similarity:
100
N.A.
93.3
40
N.A.
80
93.3
N.A.
N.A.
26.6
20
53.3
N.A.
26.6
46.6
40
46.6
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
33.3
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
7
14
7
7
0
0
0
7
0
7
7
0
7
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
14
0
7
0
27
7
20
0
7
7
14
0
7
% D
% Glu:
20
7
0
0
20
20
34
14
34
7
47
7
27
0
7
% E
% Phe:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
7
14
40
0
40
0
0
0
0
0
20
0
14
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
0
7
0
0
% H
% Ile:
27
0
0
0
0
0
0
0
0
0
7
0
0
7
0
% I
% Lys:
0
0
0
0
7
7
7
14
7
14
7
7
0
14
14
% K
% Leu:
0
0
0
7
0
0
0
0
7
0
0
7
20
0
0
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
7
0
0
20
0
0
0
7
7
0
20
7
% N
% Pro:
0
0
0
0
7
0
7
7
0
7
7
14
20
0
7
% P
% Gln:
0
0
0
0
0
14
0
0
0
0
7
0
14
0
0
% Q
% Arg:
0
14
0
0
0
0
0
14
0
14
0
0
0
0
7
% R
% Ser:
14
47
40
27
14
0
0
47
14
54
0
0
0
20
27
% S
% Thr:
0
0
7
7
0
7
0
0
0
7
0
14
0
20
14
% T
% Val:
20
0
14
7
34
14
7
0
14
0
0
14
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _