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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
25.45
Human Site:
S1257
Identified Species:
40
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
S1257
H
S
L
V
E
D
Y
S
Q
N
V
A
V
R
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
S1257
H
S
L
V
E
D
Y
S
Q
N
V
A
V
R
L
Dog
Lupus familis
XP_531814
1283
145094
P1201
V
E
N
E
C
E
D
P
S
Q
E
T
I
T
F
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
S1255
H
S
L
V
E
D
Y
S
K
S
V
C
V
R
L
Rat
Rattus norvegicus
XP_002726765
1361
151628
S1258
H
S
L
V
E
D
Y
S
K
N
V
C
V
R
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
S1363
H
S
L
V
E
D
Y
S
G
S
A
A
V
R
L
Frog
Xenopus laevis
NP_001089247
1340
149481
S1239
H
S
L
V
E
D
H
S
H
S
Q
S
V
R
L
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
V1266
H
S
L
V
E
D
H
V
Q
D
P
A
V
R
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
Y1111
Q
E
T
V
T
F
L
Y
K
Y
T
A
G
A
C
Honey Bee
Apis mellifera
XP_392346
1120
127429
N1041
H
M
A
C
M
V
E
N
E
E
Q
D
K
V
S
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
P1107
D
K
E
N
N
E
D
P
T
M
E
D
V
T
F
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
S1233
H
S
L
V
E
E
F
S
H
D
P
N
I
R
L
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
V1205
P
K
S
Y
G
V
N
V
A
R
L
A
G
L
P
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
Q1206
H
R
L
S
V
D
Y
Q
T
N
P
K
V
S
L
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
A1163
I
D
N
A
Q
I
A
A
D
N
L
E
H
T
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
0
N.A.
80
86.6
N.A.
N.A.
80
66.6
73.3
N.A.
13.3
6.6
6.6
53.3
P-Site Similarity:
100
N.A.
100
13.3
N.A.
93.3
93.3
N.A.
N.A.
86.6
86.6
86.6
N.A.
20
20
13.3
80
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
6.6
N.A.
N.A.
46.6
6.6
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
46.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
7
0
0
7
7
7
0
7
40
0
7
0
% A
% Cys:
0
0
0
7
7
0
0
0
0
0
0
14
0
0
7
% C
% Asp:
7
7
0
0
0
54
14
0
7
14
0
14
0
0
0
% D
% Glu:
0
14
7
7
54
20
7
0
7
7
14
7
0
0
0
% E
% Phe:
0
0
0
0
0
7
7
0
0
0
0
0
0
0
14
% F
% Gly:
0
0
0
0
7
0
0
0
7
0
0
0
14
0
0
% G
% His:
67
0
0
0
0
0
14
0
14
0
0
0
7
0
0
% H
% Ile:
7
0
0
0
0
7
0
0
0
0
0
0
14
0
0
% I
% Lys:
0
14
0
0
0
0
0
0
20
0
0
7
7
0
0
% K
% Leu:
0
0
60
0
0
0
7
0
0
0
14
0
0
7
60
% L
% Met:
0
7
0
0
7
0
0
0
0
7
0
0
0
0
0
% M
% Asn:
0
0
14
7
7
0
7
7
0
34
0
7
0
0
0
% N
% Pro:
7
0
0
0
0
0
0
14
0
0
20
0
0
0
7
% P
% Gln:
7
0
0
0
7
0
0
7
20
7
14
0
0
0
0
% Q
% Arg:
0
7
0
0
0
0
0
0
0
7
0
0
0
54
0
% R
% Ser:
0
54
7
7
0
0
0
47
7
20
0
7
0
7
14
% S
% Thr:
0
0
7
0
7
0
0
0
14
0
7
7
0
20
0
% T
% Val:
7
0
0
60
7
14
0
14
0
0
27
0
60
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
0
0
40
7
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _