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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AFF3
All Species:
21.21
Human Site:
S525
Identified Species:
66.67
UniProt:
P51826
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51826
NP_001020279.1
1226
133476
S525
L
R
E
K
E
I
K
S
T
C
K
E
E
Q
R
Chimpanzee
Pan troglodytes
Q7YQM2
1272
140491
T535
E
V
Q
M
K
V
K
T
N
A
S
Q
V
P
A
Rhesus Macaque
Macaca mulatta
XP_001104149
1255
136600
S554
L
R
E
K
E
V
K
S
T
C
K
E
E
Q
R
Dog
Lupus familis
XP_854360
1246
135013
S546
L
R
D
K
D
I
K
S
A
C
K
E
E
Q
R
Cat
Felis silvestris
Mouse
Mus musculus
P51827
1254
136112
T553
L
R
D
K
E
L
K
T
T
C
K
E
E
Q
R
Rat
Rattus norvegicus
XP_343560
1225
132560
T512
L
R
D
K
E
L
K
T
A
C
K
E
E
Q
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507403
1221
131271
L529
S
G
Q
C
Y
G
R
L
K
D
D
G
S
G
C
Chicken
Gallus gallus
XP_001233772
1353
145477
S630
E
S
D
S
E
S
E
S
S
S
S
E
S
D
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
31.6
95.3
90.2
N.A.
85.7
85.8
N.A.
62.6
61.5
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
47.9
96.2
93.5
N.A.
90.1
91.1
N.A.
72.7
69.7
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
93.3
80
N.A.
80
73.3
N.A.
0
20
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
40
100
93.3
N.A.
100
93.3
N.A.
13.3
40
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
25
13
0
0
0
0
13
% A
% Cys:
0
0
0
13
0
0
0
0
0
63
0
0
0
0
13
% C
% Asp:
0
0
50
0
13
0
0
0
0
13
13
0
0
13
0
% D
% Glu:
25
0
25
0
63
0
13
0
0
0
0
75
63
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
13
0
0
0
13
0
0
0
0
0
13
0
13
13
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
25
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
63
13
0
75
0
13
0
63
0
0
0
0
% K
% Leu:
63
0
0
0
0
25
0
13
0
0
0
0
0
0
0
% L
% Met:
0
0
0
13
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
13
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
13
0
% P
% Gln:
0
0
25
0
0
0
0
0
0
0
0
13
0
63
0
% Q
% Arg:
0
63
0
0
0
0
13
0
0
0
0
0
0
0
63
% R
% Ser:
13
13
0
13
0
13
0
50
13
13
25
0
25
0
0
% S
% Thr:
0
0
0
0
0
0
0
38
38
0
0
0
0
0
0
% T
% Val:
0
13
0
0
0
25
0
0
0
0
0
0
13
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
13
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _