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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLCN5 All Species: 26.67
Human Site: Y425 Identified Species: 48.89
UniProt: P51795 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51795 NP_000075.1 746 83147 Y425 R P A G V G V Y S A M W Q L A
Chimpanzee Pan troglodytes XP_001154165 791 87957 V469 D R P A G I G V Y S A I W Q L
Rhesus Macaque Macaca mulatta XP_001083068 746 83128 Y425 R P A G V G V Y S A M W Q L A
Dog Lupus familis XP_549002 992 108374 Y671 R P A G V G V Y S A M W Q L A
Cat Felis silvestris
Mouse Mus musculus Q9WVD4 746 83082 Y425 R P A G V G I Y S A M W Q L A
Rat Rattus norvegicus P51796 746 83049 Y425 R P A G V G V Y S A M W Q L A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515028 869 97095 V547 D R P A G V G V Y T A M W Q L
Chicken Gallus gallus XP_420265 942 104254 Y621 R A A G P G V Y T A M W Q L A
Frog Xenopus laevis NP_001080969 808 90050 Y487 R A A G N G V Y T A M W Q L S
Zebra Danio Brachydanio rerio XP_001920783 811 89757 V489 D R P A G P D V Y T A M W Q L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VGH7 1193 133629 T508 T H W M T S Y T S V F G N L V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92943 792 87043 F426 Y N D L A T I F F N T Q D D A
Baker's Yeast Sacchar. cerevisiae P37020 779 87664 L438 N T H A F E F L K I F T S L C
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 72.6 99.7 74.2 N.A. 97.9 98.2 N.A. 66.5 71 79.2 76.6 N.A. 20.5 N.A. N.A. N.A.
Protein Similarity: 100 83.3 100 74.9 N.A. 99.3 99.4 N.A. 76.8 75.3 85.6 84.4 N.A. 35.2 N.A. N.A. N.A.
P-Site Identity: 100 0 100 100 N.A. 93.3 100 N.A. 0 80 73.3 0 N.A. 13.3 N.A. N.A. N.A.
P-Site Similarity: 100 6.6 100 100 N.A. 100 100 N.A. 0 86.6 86.6 0 N.A. 13.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 28 32.3 N.A.
Protein Similarity: N.A. N.A. N.A. 48.2 53.5 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 16 54 31 8 0 0 0 0 54 24 0 0 0 54 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % C
% Asp: 24 0 8 0 0 0 8 0 0 0 0 0 8 8 0 % D
% Glu: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 8 0 8 8 8 0 16 0 0 0 0 % F
% Gly: 0 0 0 54 24 54 16 0 0 0 0 8 0 0 0 % G
% His: 0 8 8 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 8 16 0 0 8 0 8 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % K
% Leu: 0 0 0 8 0 0 0 8 0 0 0 0 0 70 24 % L
% Met: 0 0 0 8 0 0 0 0 0 0 54 16 0 0 0 % M
% Asn: 8 8 0 0 8 0 0 0 0 8 0 0 8 0 0 % N
% Pro: 0 39 24 0 8 8 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 8 54 24 0 % Q
% Arg: 54 24 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 8 0 0 47 8 0 0 8 0 8 % S
% Thr: 8 8 0 0 8 8 0 8 16 16 8 8 0 0 0 % T
% Val: 0 0 0 0 39 8 47 24 0 8 0 0 0 0 8 % V
% Trp: 0 0 8 0 0 0 0 0 0 0 0 54 24 0 0 % W
% Tyr: 8 0 0 0 0 0 8 54 24 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _