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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
KCNQ1
All Species:
4.85
Human Site:
S457
Identified Species:
11.85
UniProt:
P51787
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51787
NP_000209.2
676
74699
S457
E
R
R
L
D
H
F
S
V
D
G
Y
D
S
S
Chimpanzee
Pan troglodytes
XP_518580
923
101301
W456
P
T
K
V
Q
K
S
W
S
F
N
D
R
T
R
Rhesus Macaque
Macaca mulatta
XP_001112016
932
102223
W465
P
T
K
V
Q
K
S
W
S
F
N
D
R
T
R
Dog
Lupus familis
XP_540790
888
97287
S673
E
R
R
P
D
H
F
S
V
D
N
C
D
S
S
Cat
Felis silvestris
Mouse
Mus musculus
P97414
668
74510
H454
P
E
D
R
R
P
D
H
F
S
I
D
G
Y
D
Rat
Rattus norvegicus
Q9Z0N7
669
74561
H455
P
E
D
R
R
P
D
H
F
S
I
D
G
Y
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_421022
643
72527
D430
T
Y
D
H
V
T
D
D
K
K
P
D
F
C
F
Frog
Xenopus laevis
P70057
377
42627
I164
L
R
F
A
R
K
P
I
S
V
I
D
L
I
V
Zebra Danio
Brachydanio rerio
NP_001116714
655
73693
S441
R
R
Y
E
R
A
P
S
W
N
S
L
S
S
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_496875
621
70561
E408
S
T
D
V
E
M
G
E
L
Q
Q
E
R
L
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
31.5
31.5
63.2
N.A.
88
89.1
N.A.
N.A.
76.4
45.8
59
N.A.
N.A.
N.A.
46.7
N.A.
Protein Similarity:
100
45.2
45
68.1
N.A.
92
92.7
N.A.
N.A.
83.7
50.1
70.7
N.A.
N.A.
N.A.
60
N.A.
P-Site Identity:
100
0
0
80
N.A.
0
0
N.A.
N.A.
0
6.6
20
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
100
20
20
80
N.A.
0
0
N.A.
N.A.
0
6.6
26.6
N.A.
N.A.
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
10
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
10
0
10
0
% C
% Asp:
0
0
40
0
20
0
30
10
0
20
0
60
20
0
20
% D
% Glu:
20
20
0
10
10
0
0
10
0
0
0
10
0
0
0
% E
% Phe:
0
0
10
0
0
0
20
0
20
20
0
0
10
0
20
% F
% Gly:
0
0
0
0
0
0
10
0
0
0
10
0
20
0
0
% G
% His:
0
0
0
10
0
20
0
20
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
10
0
0
30
0
0
10
0
% I
% Lys:
0
0
20
0
0
30
0
0
10
10
0
0
0
0
0
% K
% Leu:
10
0
0
10
0
0
0
0
10
0
0
10
10
10
10
% L
% Met:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
10
30
0
0
0
0
% N
% Pro:
40
0
0
10
0
20
20
0
0
0
10
0
0
0
0
% P
% Gln:
0
0
0
0
20
0
0
0
0
10
10
0
0
0
0
% Q
% Arg:
10
40
20
20
40
0
0
0
0
0
0
0
30
0
20
% R
% Ser:
10
0
0
0
0
0
20
30
30
20
10
0
10
30
20
% S
% Thr:
10
30
0
0
0
10
0
0
0
0
0
0
0
20
0
% T
% Val:
0
0
0
30
10
0
0
0
20
10
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
20
10
0
0
0
0
0
0
% W
% Tyr:
0
10
10
0
0
0
0
0
0
0
0
10
0
20
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _