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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
KCNQ1
All Species:
13.64
Human Site:
S373
Identified Species:
33.33
UniProt:
P51787
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51787
NP_000209.2
676
74699
S373
R
Q
I
P
A
A
A
S
L
I
Q
T
A
W
R
Chimpanzee
Pan troglodytes
XP_518580
923
101301
L373
R
R
N
P
A
A
N
L
I
Q
C
V
W
R
S
Rhesus Macaque
Macaca mulatta
XP_001112016
932
102223
N372
K
R
R
N
P
A
A
N
L
I
Q
C
V
W
R
Dog
Lupus familis
XP_540790
888
97287
S588
R
Q
I
P
A
A
A
S
L
I
Q
T
A
W
R
Cat
Felis silvestris
Mouse
Mus musculus
P97414
668
74510
S372
R
Q
I
P
A
A
A
S
L
I
Q
T
A
W
R
Rat
Rattus norvegicus
Q9Z0N7
669
74561
S373
R
Q
I
P
A
A
A
S
L
I
Q
T
A
W
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_421022
643
72527
P348
K
H
F
N
R
Q
I
P
A
A
A
S
L
I
Q
Frog
Xenopus laevis
P70057
377
42627
R82
R
V
Y
N
F
L
E
R
P
T
G
W
K
C
F
Zebra Danio
Brachydanio rerio
NP_001116714
655
73693
A358
A
L
L
N
P
D
S
A
T
Y
K
L
F
V
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_496875
621
70561
A326
N
R
Q
I
P
A
A
A
T
L
I
Q
C
L
W
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
31.5
31.5
63.2
N.A.
88
89.1
N.A.
N.A.
76.4
45.8
59
N.A.
N.A.
N.A.
46.7
N.A.
Protein Similarity:
100
45.2
45
68.1
N.A.
92
92.7
N.A.
N.A.
83.7
50.1
70.7
N.A.
N.A.
N.A.
60
N.A.
P-Site Identity:
100
26.6
46.6
100
N.A.
100
100
N.A.
N.A.
0
6.6
0
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
100
40
66.6
100
N.A.
100
100
N.A.
N.A.
20
6.6
33.3
N.A.
N.A.
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
50
70
60
20
10
10
10
0
40
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
10
10
10
10
0
% C
% Asp:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
10
0
10
0
0
0
0
0
0
0
10
0
10
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% G
% His:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
40
10
0
0
10
0
10
50
10
0
0
10
0
% I
% Lys:
20
0
0
0
0
0
0
0
0
0
10
0
10
0
10
% K
% Leu:
0
10
10
0
0
10
0
10
50
10
0
10
10
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
10
40
0
0
10
10
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
50
30
0
0
10
10
0
0
0
0
0
0
% P
% Gln:
0
40
10
0
0
10
0
0
0
10
50
10
0
0
10
% Q
% Arg:
60
30
10
0
10
0
0
10
0
0
0
0
0
10
50
% R
% Ser:
0
0
0
0
0
0
10
40
0
0
0
10
0
0
10
% S
% Thr:
0
0
0
0
0
0
0
0
20
10
0
40
0
0
0
% T
% Val:
0
10
0
0
0
0
0
0
0
0
0
10
10
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
10
10
50
10
% W
% Tyr:
0
0
10
0
0
0
0
0
0
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _