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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METAP2
All Species:
52.73
Human Site:
Y454
Identified Species:
77.33
UniProt:
P50579
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P50579
NP_006829.1
478
52892
Y454
L
C
D
I
K
G
S
Y
T
A
Q
F
E
H
T
Chimpanzee
Pan troglodytes
XP_509279
506
55752
Y482
L
C
D
I
K
G
S
Y
T
A
Q
F
E
H
T
Rhesus Macaque
Macaca mulatta
XP_001107008
478
52846
Y454
L
C
D
I
K
G
S
Y
T
A
Q
F
E
H
T
Dog
Lupus familis
XP_866154
477
52787
Y453
L
C
D
I
K
G
S
Y
T
A
Q
F
E
H
T
Cat
Felis silvestris
Mouse
Mus musculus
O08663
478
52903
Y454
L
C
D
I
K
G
S
Y
T
A
Q
F
E
H
T
Rat
Rattus norvegicus
P38062
478
53033
Y454
L
C
D
I
K
G
S
Y
T
A
Q
F
E
H
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514935
562
60510
Y538
L
C
D
I
K
G
S
Y
T
A
Q
F
E
H
T
Chicken
Gallus gallus
NP_001006233
479
53005
Y455
L
C
D
I
K
G
S
Y
T
A
Q
F
E
H
T
Frog
Xenopus laevis
NP_001080472
462
51462
Y438
L
C
D
M
K
G
S
Y
T
A
Q
F
E
H
T
Zebra Danio
Brachydanio rerio
NP_955934
476
53163
Y452
L
C
D
T
K
G
C
Y
T
A
Q
F
E
H
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477373
448
49786
Y424
L
C
D
I
K
G
C
Y
T
A
Q
Y
E
H
T
Honey Bee
Apis mellifera
XP_624161
474
52546
Y450
L
V
D
V
K
G
C
Y
T
A
Q
F
E
H
T
Nematode Worm
Caenorhab. elegans
P50581
182
20674
A159
R
W
M
A
M
V
G
A
C
I
L
Q
S
F
A
Sea Urchin
Strong. purpuratus
XP_780497
508
56248
Y484
L
C
D
V
K
G
C
Y
T
A
Q
Y
E
H
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q56Y85
439
49041
V416
C
D
V
K
G
S
Y
V
S
Q
F
E
H
T
I
Baker's Yeast
Sacchar. cerevisiae
P38174
421
47484
T398
N
D
I
P
G
S
Y
T
A
Q
F
E
H
T
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.4
99.1
97.9
N.A.
94.9
94.9
N.A.
73.1
86.8
80.7
78.6
N.A.
62.7
63.5
22.7
67.3
Protein Similarity:
100
94.4
99.3
98.9
N.A.
96.6
97
N.A.
78.1
93.1
88
87.4
N.A.
75.9
79
29.2
76.7
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
93.3
86.6
N.A.
86.6
80
0
80
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
86.6
N.A.
93.3
86.6
0
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
61.5
48.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
73.2
63.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
0
0
7
7
82
0
0
0
0
7
% A
% Cys:
7
75
0
0
0
0
25
0
7
0
0
0
0
0
0
% C
% Asp:
0
13
82
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
13
82
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
13
69
0
7
0
% F
% Gly:
0
0
0
0
13
82
7
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
13
82
0
% H
% Ile:
0
0
7
57
0
0
0
0
0
7
0
0
0
0
13
% I
% Lys:
0
0
0
7
82
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
82
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% L
% Met:
0
0
7
7
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
13
82
7
0
0
0
% Q
% Arg:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
13
57
0
7
0
0
0
7
0
0
% S
% Thr:
0
0
0
7
0
0
0
7
82
0
0
0
0
13
82
% T
% Val:
0
7
7
13
0
7
0
7
0
0
0
0
0
0
0
% V
% Trp:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
13
82
0
0
0
13
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _