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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: METAP2 All Species: 4.55
Human Site: S74 Identified Species: 6.67
UniProt: P50579 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P50579 NP_006829.1 478 52892 S74 V A R Q L E R S A L E D K E R
Chimpanzee Pan troglodytes XP_509279 506 55752 S74 V A R Q L E R S A L E D K E R
Rhesus Macaque Macaca mulatta XP_001107008 478 52846 Q74 V A R Q L E R Q A L E D K E R
Dog Lupus familis XP_866154 477 52787 Q73 V A R Q L E R Q A L E E K E R
Cat Felis silvestris
Mouse Mus musculus O08663 478 52903 Q74 V A K Q L E S Q A L E E K E R
Rat Rattus norvegicus P38062 478 53033 Q74 V A K Q L E R Q A L E E K E K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514935 562 60510 Q154 R S P Q L Q K Q S P Q R P E S
Chicken Gallus gallus NP_001006233 479 53005 Q75 V A K Q L D K Q A L E E K D K
Frog Xenopus laevis NP_001080472 462 51462 E70 K E K D E D E E D G E G D A D
Zebra Danio Brachydanio rerio NP_955934 476 53163 Q73 V T K Q L D Q Q T L E E Q E K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477373 448 49786 K69 P A A Q P A K K K G N K G K K
Honey Bee Apis mellifera XP_624161 474 52546 V75 D N A I D E E V D I E A T E N
Nematode Worm Caenorhab. elegans P50581 182 20674
Sea Urchin Strong. purpuratus XP_780497 508 56248 H75 V T E D L R N H N L D E K Q P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q56Y85 439 49041 K63 A E T S T K K K K K K N K S K
Baker's Yeast Sacchar. cerevisiae P38174 421 47484 N45 V E S K K K K N K K K K K K K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.4 99.1 97.9 N.A. 94.9 94.9 N.A. 73.1 86.8 80.7 78.6 N.A. 62.7 63.5 22.7 67.3
Protein Similarity: 100 94.4 99.3 98.9 N.A. 96.6 97 N.A. 78.1 93.1 88 87.4 N.A. 75.9 79 29.2 76.7
P-Site Identity: 100 100 93.3 86.6 N.A. 73.3 73.3 N.A. 20 53.3 6.6 40 N.A. 13.3 20 0 26.6
P-Site Similarity: 100 100 93.3 93.3 N.A. 86.6 93.3 N.A. 53.3 93.3 20 80 N.A. 33.3 26.6 0 46.6
Percent
Protein Identity: N.A. N.A. N.A. 61.5 48.7 N.A.
Protein Similarity: N.A. N.A. N.A. 73.2 63.1 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 50 13 0 0 7 0 0 44 0 0 7 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 0 13 7 19 0 0 13 0 7 19 7 7 7 % D
% Glu: 0 19 7 0 7 44 13 7 0 0 63 38 0 57 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 13 0 7 7 0 0 % G
% His: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 7 0 0 0 0 0 7 0 0 0 0 0 % I
% Lys: 7 0 32 7 7 13 32 13 19 13 13 13 63 13 38 % K
% Leu: 0 0 0 0 63 0 0 0 0 57 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 7 0 0 0 0 7 7 7 0 7 7 0 0 7 % N
% Pro: 7 0 7 0 7 0 0 0 0 7 0 0 7 0 7 % P
% Gln: 0 0 0 63 0 7 7 44 0 0 7 0 7 7 0 % Q
% Arg: 7 0 25 0 0 7 32 0 0 0 0 7 0 0 32 % R
% Ser: 0 7 7 7 0 0 7 13 7 0 0 0 0 7 7 % S
% Thr: 0 13 7 0 7 0 0 0 7 0 0 0 7 0 0 % T
% Val: 63 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _