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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METAP2
All Species:
8.79
Human Site:
S49
Identified Species:
12.89
UniProt:
P50579
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P50579
NP_006829.1
478
52892
S49
K
K
K
S
K
G
P
S
A
A
G
E
Q
E
P
Chimpanzee
Pan troglodytes
XP_509279
506
55752
S49
K
K
K
S
K
G
P
S
A
A
G
E
Q
E
P
Rhesus Macaque
Macaca mulatta
XP_001107008
478
52846
S49
K
K
K
S
K
G
A
S
A
A
G
E
Q
E
P
Dog
Lupus familis
XP_866154
477
52787
A48
K
K
K
K
S
K
G
A
A
T
G
Q
Q
E
P
Cat
Felis silvestris
Mouse
Mus musculus
O08663
478
52903
V49
K
K
K
G
K
G
A
V
S
A
V
Q
Q
E
L
Rat
Rattus norvegicus
P38062
478
53033
V49
K
K
K
G
K
G
A
V
S
A
G
Q
Q
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514935
562
60510
A129
D
P
G
V
R
T
G
A
S
A
V
S
A
A
P
Chicken
Gallus gallus
NP_001006233
479
53005
V50
K
K
K
K
K
G
K
V
G
P
A
G
Q
E
T
Frog
Xenopus laevis
NP_001080472
462
51462
A45
E
K
D
L
G
A
T
A
I
A
T
E
E
I
T
Zebra Danio
Brachydanio rerio
NP_955934
476
53163
K48
K
K
K
K
K
K
G
K
A
A
A
V
E
N
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477373
448
49786
G44
A
A
A
K
I
A
S
G
E
G
G
D
E
E
L
Honey Bee
Apis mellifera
XP_624161
474
52546
A50
K
K
K
K
K
A
G
A
G
E
A
S
A
D
V
Nematode Worm
Caenorhab. elegans
P50581
182
20674
Sea Urchin
Strong. purpuratus
XP_780497
508
56248
K50
K
R
R
R
K
K
K
K
N
T
G
G
V
N
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q56Y85
439
49041
L38
E
S
E
L
S
K
K
L
E
I
A
E
D
G
Q
Baker's Yeast
Sacchar. cerevisiae
P38174
421
47484
E20
D
L
K
E
L
N
L
E
N
E
G
V
E
Q
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.4
99.1
97.9
N.A.
94.9
94.9
N.A.
73.1
86.8
80.7
78.6
N.A.
62.7
63.5
22.7
67.3
Protein Similarity:
100
94.4
99.3
98.9
N.A.
96.6
97
N.A.
78.1
93.1
88
87.4
N.A.
75.9
79
29.2
76.7
P-Site Identity:
100
100
93.3
53.3
N.A.
53.3
60
N.A.
13.3
46.6
20
40
N.A.
13.3
26.6
0
20
P-Site Similarity:
100
100
93.3
66.6
N.A.
66.6
73.3
N.A.
33.3
46.6
40
46.6
N.A.
26.6
40
0
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
61.5
48.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
73.2
63.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
7
0
0
19
19
25
32
50
25
0
13
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
13
0
7
0
0
0
0
0
0
0
0
7
7
7
0
% D
% Glu:
13
0
7
7
0
0
0
7
13
13
0
32
25
50
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
7
13
7
38
25
7
13
7
50
13
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
0
0
0
0
7
0
0
0
7
7
0
0
0
7
0
% I
% Lys:
63
63
63
32
57
25
19
13
0
0
0
0
0
0
0
% K
% Leu:
0
7
0
13
7
0
7
7
0
0
0
0
0
0
19
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
7
0
0
13
0
0
0
0
13
0
% N
% Pro:
0
7
0
0
0
0
13
0
0
7
0
0
0
0
32
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
19
44
7
13
% Q
% Arg:
0
7
7
7
7
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
7
0
19
13
0
7
19
19
0
0
13
0
0
0
% S
% Thr:
0
0
0
0
0
7
7
0
0
13
7
0
0
0
13
% T
% Val:
0
0
0
7
0
0
0
19
0
0
13
13
7
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _