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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HNMT
All Species:
41.82
Human Site:
S174
Identified Species:
92
UniProt:
P50135
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P50135
NP_008826.1
292
33295
S174
K
M
L
I
I
V
V
S
G
S
S
G
W
D
K
Chimpanzee
Pan troglodytes
XP_001155975
292
33249
S174
K
M
L
I
I
V
V
S
G
S
S
G
W
D
K
Rhesus Macaque
Macaca mulatta
XP_001094746
292
33293
S174
K
I
L
I
I
V
V
S
G
S
S
G
W
D
K
Dog
Lupus familis
XP_533340
292
33548
S174
K
M
L
I
I
L
V
S
G
N
S
G
W
D
K
Cat
Felis silvestris
Mouse
Mus musculus
Q91VF2
295
33646
S175
K
I
L
I
I
L
V
S
G
T
S
G
W
E
K
Rat
Rattus norvegicus
Q01984
295
33923
S175
K
I
L
I
I
L
V
S
G
T
S
G
W
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510925
320
35175
S202
R
I
L
I
I
L
V
S
G
S
S
G
W
A
H
Chicken
Gallus gallus
XP_422143
292
32869
S174
K
L
L
I
I
L
V
S
E
T
S
G
W
E
T
Frog
Xenopus laevis
Q5U4V2
293
33067
S174
K
L
L
I
I
L
V
S
G
N
S
G
W
A
T
Zebra Danio
Brachydanio rerio
Q6DC37
292
33600
S174
K
L
L
I
I
L
V
S
G
E
S
G
W
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786900
298
33811
S176
I
L
L
I
I
V
V
S
V
A
G
G
F
W
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
92.4
87.6
N.A.
83
83.3
N.A.
49.3
59.9
59
43.8
N.A.
N.A.
N.A.
N.A.
31.5
Protein Similarity:
100
99.6
95.5
93.1
N.A.
92.5
91.5
N.A.
67.8
79.4
78.5
66.7
N.A.
N.A.
N.A.
N.A.
58.3
P-Site Identity:
100
100
93.3
86.6
N.A.
73.3
73.3
N.A.
66.6
60
66.6
73.3
N.A.
N.A.
N.A.
N.A.
46.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
86.6
86.6
86.6
86.6
N.A.
N.A.
N.A.
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
10
0
0
0
19
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
37
0
% D
% Glu:
0
0
0
0
0
0
0
0
10
10
0
0
0
28
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
82
0
10
100
0
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% H
% Ile:
10
37
0
100
100
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
82
0
0
0
0
0
0
0
0
0
0
0
0
0
64
% K
% Leu:
0
37
100
0
0
64
0
0
0
0
0
0
0
0
0
% L
% Met:
0
28
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
19
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% R
% Ser:
0
0
0
0
0
0
0
100
0
37
91
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
28
0
0
0
0
19
% T
% Val:
0
0
0
0
0
37
100
0
10
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
91
10
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _