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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MRE11A All Species: 32.12
Human Site: Y436 Identified Species: 50.48
UniProt: P49959 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49959 NP_005581.2 708 80593 Y436 V E D L V K Q Y F Q T A E K N
Chimpanzee Pan troglodytes XP_001142343 708 80653 Y436 V E D L V K Q Y F Q T A E K N
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_542244 708 80700 Y436 V E D L V K Q Y F Q T A E K N
Cat Felis silvestris
Mouse Mus musculus Q61216 706 80204 Y437 V E D L V K Q Y F Q T A E K N
Rat Rattus norvegicus Q9JIM0 706 80103 Y437 V E D L V K Q Y F Q T A E K N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513434 706 80323 Y437 V E D L V K Q Y F Q T A E K N
Chicken Gallus gallus Q9IAM7 700 80005 Y437 V E D L V K Q Y F Q T A E K K
Frog Xenopus laevis Q9W6K1 711 81112 Y439 V E D L V K E Y F K T A E K N
Zebra Danio Brachydanio rerio NP_001001407 619 70401 D369 P L I R L R V D Y S G G F E V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_523547 620 69267 Q370 Q H T G H P K Q P T L P L I R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23255 728 81540 A461 Y E N V V A N A V D M V F I K
Sea Urchin Strong. purpuratus XP_798167 515 58684 S269 P G S S I A T S L S P G E A E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9XGM2 720 80272 N425 P E E L N Q Q N I E A L V A E
Baker's Yeast Sacchar. cerevisiae P32829 692 77632 L436 S D R D V E K L F S E S G G E
Red Bread Mold Neurospora crassa Q9C291 739 83526 F445 V D N L V Q E F F A Q Q S L K
Conservation
Percent
Protein Identity: 100 99.4 N.A. 93.7 N.A. 88.2 88.4 N.A. 85 73.5 72.8 61.2 N.A. 39.5 N.A. 32.6 42.6
Protein Similarity: 100 99.4 N.A. 97.1 N.A. 93.7 93.7 N.A. 92.3 85.5 85 75.2 N.A. 55.6 N.A. 50.6 56.9
P-Site Identity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 93.3 86.6 0 N.A. 0 N.A. 13.3 6.6
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 93.3 100 26.6 N.A. 6.6 N.A. 26.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. 38.1 35.3 33.8
Protein Similarity: N.A. N.A. N.A. 57.9 53.3 52.5
P-Site Identity: N.A. N.A. N.A. 20 13.3 26.6
P-Site Similarity: N.A. N.A. N.A. 40 40 60
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 14 0 7 0 7 7 54 0 14 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 14 54 7 0 0 0 7 0 7 0 0 0 0 0 % D
% Glu: 0 67 7 0 0 7 14 0 0 7 7 0 60 7 20 % E
% Phe: 0 0 0 0 0 0 0 7 67 0 0 0 14 0 0 % F
% Gly: 0 7 0 7 0 0 0 0 0 0 7 14 7 7 0 % G
% His: 0 7 0 0 7 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 7 0 7 0 0 0 7 0 0 0 0 14 0 % I
% Lys: 0 0 0 0 0 54 14 0 0 7 0 0 0 54 20 % K
% Leu: 0 7 0 67 7 0 0 7 7 0 7 7 7 7 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % M
% Asn: 0 0 14 0 7 0 7 7 0 0 0 0 0 0 47 % N
% Pro: 20 0 0 0 0 7 0 0 7 0 7 7 0 0 0 % P
% Gln: 7 0 0 0 0 14 54 7 0 47 7 7 0 0 0 % Q
% Arg: 0 0 7 7 0 7 0 0 0 0 0 0 0 0 7 % R
% Ser: 7 0 7 7 0 0 0 7 0 20 0 7 7 0 0 % S
% Thr: 0 0 7 0 0 0 7 0 0 7 54 0 0 0 0 % T
% Val: 60 0 0 7 74 0 7 0 7 0 0 7 7 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 0 0 0 0 0 54 7 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _