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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
17.27
Human Site:
S558
Identified Species:
27.14
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
S558
A
E
Q
M
A
N
D
S
D
D
S
I
S
A
A
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
S558
A
E
Q
M
A
N
D
S
D
D
S
I
S
A
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
S558
A
E
Q
M
A
D
D
S
D
E
D
T
S
A
A
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
D559
E
Q
T
A
N
D
S
D
D
S
L
S
A
V
P
Rat
Rattus norvegicus
Q9JIM0
706
80103
D559
E
Q
T
A
D
D
S
D
D
S
Q
S
A
V
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
S559
A
E
Q
M
A
N
D
S
D
D
S
I
S
A
M
Chicken
Gallus gallus
Q9IAM7
700
80005
T549
S
D
E
G
L
M
D
T
G
M
K
A
S
G
D
Frog
Xenopus laevis
Q9W6K1
711
81112
D558
R
K
V
S
L
S
D
D
E
D
V
R
A
S
M
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
E469
Q
E
F
V
D
K
E
E
R
D
A
I
E
E
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
T471
S
K
A
L
A
E
M
T
Y
R
L
L
E
Q
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
K565
D
V
V
R
K
T
L
K
K
M
P
L
P
P
I
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
T369
D
Y
S
G
G
F
D
T
I
N
V
N
R
F
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
A533
T
K
G
S
S
G
I
A
N
A
S
F
S
D
D
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
N544
T
N
F
A
F
N
G
N
G
L
D
S
F
R
S
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
E581
S
G
V
T
F
S
D
E
D
E
D
M
D
M
D
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
100
N.A.
73.3
N.A.
6.6
6.6
N.A.
93.3
13.3
13.3
20
N.A.
6.6
N.A.
0
6.6
P-Site Similarity:
100
100
N.A.
86.6
N.A.
26.6
26.6
N.A.
93.3
40
46.6
40
N.A.
40
N.A.
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
40
20
40
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
27
0
7
20
34
0
0
7
0
7
7
7
20
27
20
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
14
7
0
0
14
20
54
20
47
34
20
0
7
7
20
% D
% Glu:
14
34
7
0
0
7
7
14
7
14
0
0
14
7
0
% E
% Phe:
0
0
14
0
14
7
0
0
0
0
0
7
7
7
0
% F
% Gly:
0
7
7
14
7
7
7
0
14
0
0
0
0
7
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
7
0
7
0
0
27
0
0
7
% I
% Lys:
0
20
0
0
7
7
0
7
7
0
7
0
0
0
0
% K
% Leu:
0
0
0
7
14
0
7
0
0
7
14
14
0
0
7
% L
% Met:
0
0
0
27
0
7
7
0
0
14
0
7
0
7
14
% M
% Asn:
0
7
0
0
7
27
0
7
7
7
0
7
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
7
0
7
7
14
% P
% Gln:
7
14
27
0
0
0
0
0
0
0
7
0
0
7
0
% Q
% Arg:
7
0
0
7
0
0
0
0
7
7
0
7
7
7
7
% R
% Ser:
20
0
7
14
7
14
14
27
0
14
27
20
40
7
7
% S
% Thr:
14
0
14
7
0
7
0
20
0
0
0
7
0
0
0
% T
% Val:
0
7
20
7
0
0
0
0
0
0
14
0
0
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
0
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _