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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MRE11A All Species: 19.09
Human Site: S422 Identified Species: 30
UniProt: P49959 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49959 NP_005581.2 708 80593 S422 G K L I T K P S E G T T L R V
Chimpanzee Pan troglodytes XP_001142343 708 80653 S422 G K L I T K P S E G T T L R V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_542244 708 80700 S422 G K L I T K P S E G T T L R V
Cat Felis silvestris
Mouse Mus musculus Q61216 706 80204 S423 M L I T K P A S E G A T L R V
Rat Rattus norvegicus Q9JIM0 706 80103 S423 K L I I K P A S E G T T L R V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513434 706 80323 S423 K F I R K P A S E G M T L R V
Chicken Gallus gallus Q9IAM7 700 80005 S423 K L L S R P A S E E V T L R V
Frog Xenopus laevis Q9W6K1 711 81112 L425 K I D S K P L L E G T T L R V
Zebra Danio Brachydanio rerio NP_001001407 619 70401 N355 A E R E R L G N P Q I P E K P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_523547 620 69267 M356 A Q E R V E A M I E R A V A Q
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23255 728 81540 A447 L N I T P A N A K R I G L R Y
Sea Urchin Strong. purpuratus XP_798167 515 58684 Q255 D P V W N A T Q N F F I S Q P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9XGM2 720 80272 D411 G R S E A N I D D S E R L R P
Baker's Yeast Sacchar. cerevisiae P32829 692 77632 G422 V T R S K K S G I N G T S I S
Red Bread Mold Neurospora crassa Q9C291 739 83526 E431 E D I A E I L E S A D T I K V
Conservation
Percent
Protein Identity: 100 99.4 N.A. 93.7 N.A. 88.2 88.4 N.A. 85 73.5 72.8 61.2 N.A. 39.5 N.A. 32.6 42.6
Protein Similarity: 100 99.4 N.A. 97.1 N.A. 93.7 93.7 N.A. 92.3 85.5 85 75.2 N.A. 55.6 N.A. 50.6 56.9
P-Site Identity: 100 100 N.A. 100 N.A. 46.6 60 N.A. 46.6 46.6 46.6 0 N.A. 0 N.A. 13.3 0
P-Site Similarity: 100 100 N.A. 100 N.A. 53.3 66.6 N.A. 53.3 46.6 46.6 20 N.A. 20 N.A. 33.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. 38.1 35.3 33.8
Protein Similarity: N.A. N.A. N.A. 57.9 53.3 52.5
P-Site Identity: N.A. N.A. N.A. 20 13.3 13.3
P-Site Similarity: N.A. N.A. N.A. 33.3 13.3 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 0 0 7 7 14 34 7 0 7 7 7 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 7 7 0 0 0 0 7 7 0 7 0 0 0 0 % D
% Glu: 7 7 7 14 7 7 0 7 54 14 7 0 7 0 0 % E
% Phe: 0 7 0 0 0 0 0 0 0 7 7 0 0 0 0 % F
% Gly: 27 0 0 0 0 0 7 7 0 47 7 7 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 34 27 0 7 7 0 14 0 14 7 7 7 0 % I
% Lys: 27 20 0 0 34 27 0 0 7 0 0 0 0 14 0 % K
% Leu: 7 20 27 0 0 7 14 7 0 0 0 0 67 0 0 % L
% Met: 7 0 0 0 0 0 0 7 0 0 7 0 0 0 0 % M
% Asn: 0 7 0 0 7 7 7 7 7 7 0 0 0 0 0 % N
% Pro: 0 7 0 0 7 34 20 0 7 0 0 7 0 0 20 % P
% Gln: 0 7 0 0 0 0 0 7 0 7 0 0 0 7 7 % Q
% Arg: 0 7 14 14 14 0 0 0 0 7 7 7 0 67 0 % R
% Ser: 0 0 7 20 0 0 7 47 7 7 0 0 14 0 7 % S
% Thr: 0 7 0 14 20 0 7 0 0 0 34 67 0 0 0 % T
% Val: 7 0 7 0 7 0 0 0 0 0 7 0 7 0 60 % V
% Trp: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _