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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LIG4 All Species: 28.48
Human Site: S498 Identified Species: 44.76
UniProt: P49917 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.29
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49917 NP_001091738.1 911 103971 S498 P P P G E K P S V F H T L S R
Chimpanzee Pan troglodytes XP_509726 911 103942 S498 P P P G E K P S V F H T L S R
Rhesus Macaque Macaca mulatta XP_001084107 642 73046 E260 I A D I E H I E K D M K H Q S
Dog Lupus familis XP_542663 911 104163 S498 P P P G E K P S V F H T L C R
Cat Felis silvestris
Mouse Mus musculus Q8BTF7 911 104067 S498 P P P G D R P S V F H T L C R
Rat Rattus norvegicus NP_001099565 911 104477 S498 P P P G D K P S V F H T L C R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90YB1 912 104431 T503 P A P N E K P T V F H S I C R
Frog Xenopus laevis NP_001081114 911 104084 S503 S G P G E K P S V F H S I C R
Zebra Danio Brachydanio rerio NP_001096593 909 103624 T503 P S P G E K P T V F H T L C R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572907 918 104813 V509 G S S N R P E V F S I G V V A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001188102 952 108709 K536 S R E G D H P K I F Y S F C K
Poplar Tree Populus trichocarpa XP_002325262 1242 139306 R503 R R F I S F C R V G N G L S D
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LL84 1219 137833 R495 R R F M S F C R V G T G L S D
Baker's Yeast Sacchar. cerevisiae Q08387 944 108496 K532 Q N S R R R V K K I L S F C S
Red Bread Mold Neurospora crassa Q7SB49 1046 118891 K576 E K C L S F V K V G G G F K A
Conservation
Percent
Protein Identity: 100 99.4 68.9 91 N.A. 86.9 86.1 N.A. N.A. 76.5 72.5 64.1 N.A. 29.7 N.A. N.A. 48.5
Protein Similarity: 100 99.7 69.8 95.5 N.A. 92.5 92 N.A. N.A. 87.1 84 79.3 N.A. 51.3 N.A. N.A. 65.4
P-Site Identity: 100 100 6.6 93.3 N.A. 80 86.6 N.A. N.A. 60 66.6 80 N.A. 0 N.A. N.A. 20
P-Site Similarity: 100 100 6.6 93.3 N.A. 93.3 93.3 N.A. N.A. 80 80 86.6 N.A. 6.6 N.A. N.A. 53.3
Percent
Protein Identity: 27.2 N.A. N.A. 27.6 25.5 29.2
Protein Similarity: 43.3 N.A. N.A. 44.9 46.9 47.2
P-Site Identity: 20 N.A. N.A. 20 0 6.6
P-Site Similarity: 26.6 N.A. N.A. 20 13.3 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 14 0 0 0 0 0 0 0 0 0 0 0 0 14 % A
% Cys: 0 0 7 0 0 0 14 0 0 0 0 0 0 54 0 % C
% Asp: 0 0 7 0 20 0 0 0 0 7 0 0 0 0 14 % D
% Glu: 7 0 7 0 47 0 7 7 0 0 0 0 0 0 0 % E
% Phe: 0 0 14 0 0 20 0 0 7 60 0 0 20 0 0 % F
% Gly: 7 7 0 54 0 0 0 0 0 20 7 27 0 0 0 % G
% His: 0 0 0 0 0 14 0 0 0 0 54 0 7 0 0 % H
% Ile: 7 0 0 14 0 0 7 0 7 7 7 0 14 0 0 % I
% Lys: 0 7 0 0 0 47 0 20 14 0 0 7 0 7 7 % K
% Leu: 0 0 0 7 0 0 0 0 0 0 7 0 54 0 0 % L
% Met: 0 0 0 7 0 0 0 0 0 0 7 0 0 0 0 % M
% Asn: 0 7 0 14 0 0 0 0 0 0 7 0 0 0 0 % N
% Pro: 47 34 54 0 0 7 60 0 0 0 0 0 0 0 0 % P
% Gln: 7 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % Q
% Arg: 14 20 0 7 14 14 0 14 0 0 0 0 0 0 54 % R
% Ser: 14 14 14 0 20 0 0 40 0 7 0 27 0 27 14 % S
% Thr: 0 0 0 0 0 0 0 14 0 0 7 40 0 0 0 % T
% Val: 0 0 0 0 0 0 14 7 74 0 0 0 7 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _