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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PSEN2
All Species:
20.61
Human Site:
Y63
Identified Species:
34.87
UniProt:
P49810
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49810
NP_000438.2
448
50140
Y63
G
E
E
D
P
D
R
Y
V
C
S
G
V
P
G
Chimpanzee
Pan troglodytes
XP_514247
448
50096
Y63
G
E
E
D
P
D
R
Y
V
C
S
G
V
P
G
Rhesus Macaque
Macaca mulatta
XP_001087264
654
71396
Y269
G
E
E
D
P
D
R
Y
V
C
S
G
V
P
G
Dog
Lupus familis
XP_547503
717
78133
Y332
F
E
D
D
A
D
H
Y
V
C
G
G
V
P
G
Cat
Felis silvestris
Mouse
Mus musculus
Q61144
448
49965
Y63
C
E
E
D
P
D
R
Y
A
C
S
G
A
P
G
Rat
Rattus norvegicus
O88777
448
50033
Y63
C
E
E
D
P
D
H
Y
A
C
S
G
V
P
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514754
455
50711
V63
Q
A
A
S
G
E
A
V
C
P
S
G
K
S
I
Chicken
Gallus gallus
Q90X07
451
50448
S69
A
D
E
D
A
S
D
S
D
V
R
V
R
E
S
Frog
Xenopus laevis
O12977
449
50256
A66
P
N
G
R
T
S
G
A
D
A
Y
N
S
E
T
Zebra Danio
Brachydanio rerio
Q90ZE4
441
49151
R64
G
D
A
G
P
V
D
R
E
R
A
D
T
P
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O02194
541
59286
G79
R
P
S
R
L
T
G
G
G
G
G
S
G
G
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52166
444
50016
L63
P
V
S
L
C
M
A
L
V
V
F
T
M
N
T
Sea Urchin
Strong. purpuratus
XP_001178622
480
53857
R90
R
P
A
N
Q
E
R
R
R
E
R
D
P
P
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SIK7
397
43993
L35
C
M
F
T
V
V
L
L
V
C
I
L
N
S
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
68.3
59.9
N.A.
95.7
95.3
N.A.
79.5
74.7
72.6
71.4
N.A.
46.5
N.A.
51.1
58.7
Protein Similarity:
100
99.7
68.3
60.6
N.A.
97
96.6
N.A.
85.2
81.8
82.8
80.1
N.A.
60.4
N.A.
67.1
69.1
P-Site Identity:
100
100
100
66.6
N.A.
80
80
N.A.
13.3
13.3
0
20
N.A.
0
N.A.
6.6
13.3
P-Site Similarity:
100
100
100
73.3
N.A.
80
80
N.A.
20
20
0
33.3
N.A.
0
N.A.
13.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.4
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.2
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
22
0
15
0
15
8
15
8
8
0
8
0
0
% A
% Cys:
22
0
0
0
8
0
0
0
8
50
0
0
0
0
0
% C
% Asp:
0
15
8
50
0
43
15
0
15
0
0
15
0
0
15
% D
% Glu:
0
43
43
0
0
15
0
0
8
8
0
0
0
15
0
% E
% Phe:
8
0
8
0
0
0
0
0
0
0
8
0
0
0
0
% F
% Gly:
29
0
8
8
8
0
15
8
8
8
15
50
8
8
43
% G
% His:
0
0
0
0
0
0
15
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
8
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% K
% Leu:
0
0
0
8
8
0
8
15
0
0
0
8
0
0
0
% L
% Met:
0
8
0
0
0
8
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
8
0
8
0
0
0
0
0
0
0
8
8
8
0
% N
% Pro:
15
15
0
0
43
0
0
0
0
8
0
0
8
58
15
% P
% Gln:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
15
0
0
15
0
0
36
15
8
8
15
0
8
0
0
% R
% Ser:
0
0
15
8
0
15
0
8
0
0
43
8
8
15
8
% S
% Thr:
0
0
0
8
8
8
0
0
0
0
0
8
8
0
15
% T
% Val:
0
8
0
0
8
15
0
8
43
15
0
8
36
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
43
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _