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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PSEN2
All Species:
23.33
Human Site:
Y319
Identified Species:
39.49
UniProt:
P49810
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49810
NP_000438.2
448
50140
Y319
Q
G
A
L
Q
L
P
Y
D
P
E
M
E
E
D
Chimpanzee
Pan troglodytes
XP_514247
448
50096
Y319
Q
G
A
L
Q
L
P
Y
D
P
E
M
E
E
D
Rhesus Macaque
Macaca mulatta
XP_001087264
654
71396
Y525
Q
G
A
L
Q
L
P
Y
D
P
E
M
E
E
D
Dog
Lupus familis
XP_547503
717
78133
Y588
Q
G
A
L
Q
L
P
Y
D
P
E
M
E
E
D
Cat
Felis silvestris
Mouse
Mus musculus
Q61144
448
49965
Y319
Q
G
A
L
Q
L
P
Y
D
P
E
M
E
E
D
Rat
Rattus norvegicus
O88777
448
50033
Y319
Q
G
A
L
Q
L
P
Y
D
P
E
M
E
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514754
455
50711
Q318
E
E
V
D
H
Q
A
Q
E
E
E
E
E
P
Q
Chicken
Gallus gallus
Q90X07
451
50448
W325
K
G
Q
S
Q
Q
A
W
D
A
E
D
E
R
E
Frog
Xenopus laevis
O12977
449
50256
Q322
G
R
M
N
Q
Q
V
Q
H
I
D
R
N
T
P
Zebra Danio
Brachydanio rerio
Q90ZE4
441
49151
S318
S
A
G
E
R
R
R
S
G
G
G
V
R
T
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O02194
541
59286
P335
Q
A
T
A
S
S
S
P
S
S
S
N
S
T
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52166
444
50016
Q312
P
K
V
K
R
I
P
Q
K
V
Q
I
E
S
N
Sea Urchin
Strong. purpuratus
XP_001178622
480
53857
E346
P
K
S
K
A
K
Q
E
P
P
V
E
E
H
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SIK7
397
43993
R279
E
H
V
G
S
S
E
R
A
E
I
S
V
P
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
68.3
59.9
N.A.
95.7
95.3
N.A.
79.5
74.7
72.6
71.4
N.A.
46.5
N.A.
51.1
58.7
Protein Similarity:
100
99.7
68.3
60.6
N.A.
97
96.6
N.A.
85.2
81.8
82.8
80.1
N.A.
60.4
N.A.
67.1
69.1
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
13.3
33.3
6.6
0
N.A.
6.6
N.A.
13.3
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
26.6
53.3
13.3
13.3
N.A.
6.6
N.A.
46.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.4
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.2
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
43
8
8
0
15
0
8
8
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
50
0
8
8
0
0
43
% D
% Glu:
15
8
0
8
0
0
8
8
8
15
58
15
72
43
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
50
8
8
0
0
0
0
8
8
8
0
0
0
0
% G
% His:
0
8
0
0
8
0
0
0
8
0
0
0
0
8
0
% H
% Ile:
0
0
0
0
0
8
0
0
0
8
8
8
0
0
0
% I
% Lys:
8
15
0
15
0
8
0
0
8
0
0
0
0
0
0
% K
% Leu:
0
0
0
43
0
43
0
0
0
0
0
0
0
0
8
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
43
0
0
0
% M
% Asn:
0
0
0
8
0
0
0
0
0
0
0
8
8
0
8
% N
% Pro:
15
0
0
0
0
0
50
8
8
50
0
0
0
15
8
% P
% Gln:
50
0
8
0
58
22
8
22
0
0
8
0
0
0
15
% Q
% Arg:
0
8
0
0
15
8
8
8
0
0
0
8
8
8
0
% R
% Ser:
8
0
8
8
15
15
8
8
8
8
8
8
8
8
0
% S
% Thr:
0
0
8
0
0
0
0
0
0
0
0
0
0
22
15
% T
% Val:
0
0
22
0
0
0
8
0
0
8
8
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
43
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _