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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PSEN2
All Species:
22.73
Human Site:
S335
Identified Species:
38.46
UniProt:
P49810
Number Species:
13
Phosphosite Substitution
Charge Score:
0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49810
NP_000438.2
448
50140
S335
Y
D
S
F
G
E
P
S
Y
P
E
V
F
E
P
Chimpanzee
Pan troglodytes
XP_514247
448
50096
S335
Y
D
S
F
G
E
P
S
Y
P
E
V
F
E
P
Rhesus Macaque
Macaca mulatta
XP_001087264
654
71396
S541
Y
D
S
F
G
E
P
S
Y
P
E
V
F
E
P
Dog
Lupus familis
XP_547503
717
78133
S604
Y
D
S
F
G
E
P
S
Y
P
E
V
F
E
P
Cat
Felis silvestris
Mouse
Mus musculus
Q61144
448
49965
S335
Y
D
S
F
G
E
P
S
Y
P
E
A
F
E
A
Rat
Rattus norvegicus
O88777
448
50033
S335
Y
D
S
F
G
E
P
S
Y
P
E
A
F
E
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514754
455
50711
G334
E
N
R
R
N
R
P
G
P
G
S
I
P
P
Q
Chicken
Gallus gallus
Q90X07
451
50448
D341
H
S
S
T
S
H
S
D
S
Q
I
L
D
T
R
Frog
Xenopus laevis
O12977
449
50256
D338
G
A
N
S
T
V
E
D
A
A
E
T
R
I
Q
Zebra Danio
Brachydanio rerio
Q90ZE4
441
49151
A334
G
V
E
S
E
H
D
A
P
Q
A
G
R
R
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O02194
541
59286
L351
T
R
A
T
Q
N
S
L
A
S
P
E
A
A
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52166
444
50016
S328
T
A
S
T
T
Q
N
S
G
V
R
V
E
R
E
Sea Urchin
Strong. purpuratus
XP_001178622
480
53857
F362
E
E
N
A
T
G
E
F
G
L
N
P
W
P
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SIK7
397
43993
E295
D
R
R
P
E
Q
A
E
N
S
E
T
F
L
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
68.3
59.9
N.A.
95.7
95.3
N.A.
79.5
74.7
72.6
71.4
N.A.
46.5
N.A.
51.1
58.7
Protein Similarity:
100
99.7
68.3
60.6
N.A.
97
96.6
N.A.
85.2
81.8
82.8
80.1
N.A.
60.4
N.A.
67.1
69.1
P-Site Identity:
100
100
100
100
N.A.
86.6
86.6
N.A.
6.6
6.6
6.6
0
N.A.
0
N.A.
20
0
P-Site Similarity:
100
100
100
100
N.A.
86.6
86.6
N.A.
20
20
13.3
6.6
N.A.
6.6
N.A.
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.4
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.2
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
8
8
0
0
8
8
15
8
8
15
8
8
22
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
43
0
0
0
0
8
15
0
0
0
0
8
0
0
% D
% Glu:
15
8
8
0
15
43
15
8
0
0
58
8
8
43
15
% E
% Phe:
0
0
0
43
0
0
0
8
0
0
0
0
50
0
0
% F
% Gly:
15
0
0
0
43
8
0
8
15
8
0
8
0
0
0
% G
% His:
8
0
0
0
0
15
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
8
8
0
8
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
8
0
8
0
8
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
15
0
8
8
8
0
8
0
8
0
0
0
0
% N
% Pro:
0
0
0
8
0
0
50
0
15
43
8
8
8
15
29
% P
% Gln:
0
0
0
0
8
15
0
0
0
15
0
0
0
0
22
% Q
% Arg:
0
15
15
8
0
8
0
0
0
0
8
0
15
15
8
% R
% Ser:
0
8
58
15
8
0
15
50
8
15
8
0
0
0
8
% S
% Thr:
15
0
0
22
22
0
0
0
0
0
0
15
0
8
0
% T
% Val:
0
8
0
0
0
8
0
0
0
8
0
36
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
43
0
0
0
0
0
0
0
43
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _