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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLK3
All Species:
11.82
Human Site:
Y448
Identified Species:
21.67
UniProt:
P49761
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49761
NP_001123500.1
638
73515
Y448
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
Chimpanzee
Pan troglodytes
XP_001136940
490
58560
R317
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
Rhesus Macaque
Macaca mulatta
XP_001100690
638
73454
Y448
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
Dog
Lupus familis
XP_535541
381
44762
R208
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
Cat
Felis silvestris
Mouse
Mus musculus
O35492
638
73779
Y448
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
Rat
Rattus norvegicus
Q63117
490
58467
R317
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001012542
490
58745
D317
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
Frog
Xenopus laevis
NP_001093358
497
58599
V324
K
N
S
S
I
R
L
V
D
F
G
S
A
T
F
Zebra Danio
Brachydanio rerio
NP_001038344
526
62655
G353
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49762
832
95705
Y622
D
S
D
Y
T
S
H
Y
N
H
K
I
N
R
E
Honey Bee
Apis mellifera
XP_395279
439
51412
I266
R
R
V
K
R
T
D
I
R
L
I
D
F
G
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51567
427
49548
K254
L
Q
R
D
V
C
Y
K
R
V
P
K
S
S
A
Baker's Yeast
Sacchar. cerevisiae
P32350
737
83824
R470
V
Q
S
L
S
K
R
R
R
E
A
S
K
G
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
76.6
97.9
59.4
N.A.
88.8
76
N.A.
N.A.
65.8
53.2
51
N.A.
34
43.2
N.A.
N.A.
Protein Similarity:
100
76.6
98.2
59.5
N.A.
89.6
76.3
N.A.
N.A.
70.6
63.4
63.3
N.A.
49.8
53.9
N.A.
N.A.
P-Site Identity:
100
0
100
0
N.A.
100
0
N.A.
N.A.
6.6
6.6
6.6
N.A.
26.6
6.6
N.A.
N.A.
P-Site Similarity:
100
26.6
100
26.6
N.A.
100
26.6
N.A.
N.A.
26.6
26.6
13.3
N.A.
60
6.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
30.7
23.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.5
41.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
8
0
0
31
8
8
8
0
31
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
24
0
% C
% Asp:
8
0
8
8
0
8
8
8
8
0
24
8
8
0
8
% D
% Glu:
0
0
24
0
24
0
0
0
0
31
0
0
0
0
39
% E
% Phe:
0
0
0
24
0
0
8
0
8
8
0
31
8
8
8
% F
% Gly:
0
0
0
0
0
0
0
8
0
8
8
0
24
16
0
% G
% His:
0
0
0
0
0
0
8
0
0
8
24
0
0
8
0
% H
% Ile:
0
0
0
8
8
0
24
8
0
0
8
8
0
0
0
% I
% Lys:
8
0
24
8
0
8
0
8
0
0
8
31
8
0
8
% K
% Leu:
8
0
0
8
0
0
31
0
0
8
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
31
8
0
24
0
0
0
0
31
0
0
0
8
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% P
% Gln:
0
16
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
8
16
0
16
8
8
31
24
0
0
0
0
8
0
% R
% Ser:
24
31
24
8
8
31
0
0
8
0
8
16
31
31
8
% S
% Thr:
0
8
0
0
31
31
0
0
0
0
8
0
8
8
0
% T
% Val:
8
31
8
8
16
8
0
8
24
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
8
31
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _