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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLK3 All Species: 11.82
Human Site: Y448 Identified Species: 21.67
UniProt: P49761 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.33
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49761 NP_001123500.1 638 73515 Y448 N S E F E T L Y N E H K S C E
Chimpanzee Pan troglodytes XP_001136940 490 58560 R317 S V K N T S I R V A D F G S A
Rhesus Macaque Macaca mulatta XP_001100690 638 73454 Y448 N S E F E T L Y N E H K S C E
Dog Lupus familis XP_535541 381 44762 R208 S V K N T S I R V A D F G S A
Cat Felis silvestris
Mouse Mus musculus O35492 638 73779 Y448 N S E F E T L Y N E H K S C E
Rat Rattus norvegicus Q63117 490 58467 R317 S V K N T S I R V A D F G S A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001012542 490 58745 D317 N T S I R V A D F G S A T F D
Frog Xenopus laevis NP_001093358 497 58599 V324 K N S S I R L V D F G S A T F
Zebra Danio Brachydanio rerio NP_001038344 526 62655 G353 A V R V V D F G S A T F D H E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P49762 832 95705 Y622 D S D Y T S H Y N H K I N R E
Honey Bee Apis mellifera XP_395279 439 51412 I266 R R V K R T D I R L I D F G S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P51567 427 49548 K254 L Q R D V C Y K R V P K S S A
Baker's Yeast Sacchar. cerevisiae P32350 737 83824 R470 V Q S L S K R R R E A S K G K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 76.6 97.9 59.4 N.A. 88.8 76 N.A. N.A. 65.8 53.2 51 N.A. 34 43.2 N.A. N.A.
Protein Similarity: 100 76.6 98.2 59.5 N.A. 89.6 76.3 N.A. N.A. 70.6 63.4 63.3 N.A. 49.8 53.9 N.A. N.A.
P-Site Identity: 100 0 100 0 N.A. 100 0 N.A. N.A. 6.6 6.6 6.6 N.A. 26.6 6.6 N.A. N.A.
P-Site Similarity: 100 26.6 100 26.6 N.A. 100 26.6 N.A. N.A. 26.6 26.6 13.3 N.A. 60 6.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 30.7 23.7 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 41.7 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 0 8 0 0 31 8 8 8 0 31 % A
% Cys: 0 0 0 0 0 8 0 0 0 0 0 0 0 24 0 % C
% Asp: 8 0 8 8 0 8 8 8 8 0 24 8 8 0 8 % D
% Glu: 0 0 24 0 24 0 0 0 0 31 0 0 0 0 39 % E
% Phe: 0 0 0 24 0 0 8 0 8 8 0 31 8 8 8 % F
% Gly: 0 0 0 0 0 0 0 8 0 8 8 0 24 16 0 % G
% His: 0 0 0 0 0 0 8 0 0 8 24 0 0 8 0 % H
% Ile: 0 0 0 8 8 0 24 8 0 0 8 8 0 0 0 % I
% Lys: 8 0 24 8 0 8 0 8 0 0 8 31 8 0 8 % K
% Leu: 8 0 0 8 0 0 31 0 0 8 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 31 8 0 24 0 0 0 0 31 0 0 0 8 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % P
% Gln: 0 16 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 8 8 16 0 16 8 8 31 24 0 0 0 0 8 0 % R
% Ser: 24 31 24 8 8 31 0 0 8 0 8 16 31 31 8 % S
% Thr: 0 8 0 0 31 31 0 0 0 0 8 0 8 8 0 % T
% Val: 8 31 8 8 16 8 0 8 24 8 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 0 8 31 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _