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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLK3 All Species: 9.7
Human Site: Y232 Identified Species: 17.78
UniProt: P49761 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49761 NP_001123500.1 638 73515 Y232 P S F G E D Y Y G P S R S R H
Chimpanzee Pan troglodytes XP_001136940 490 58560 Q126 S S A S S R S Q Q S S K R S S
Rhesus Macaque Macaca mulatta XP_001100690 638 73454 Y232 P S F G E D Y Y G S S R S R H
Dog Lupus familis XP_535541 381 44762 Q17 G R C M Q R S Q Q S S K R S S
Cat Felis silvestris
Mouse Mus musculus O35492 638 73779 Y232 P S F G E D C Y G S S R S R H
Rat Rattus norvegicus Q63117 490 58467 Q126 S S A S S R S Q Q S S K R S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001012542 490 58745 S126 A S S R S Q Q S S K R S R S V
Frog Xenopus laevis NP_001093358 497 58599 R133 Y S S S K S Q R S T K D S Q N
Zebra Danio Brachydanio rerio NP_001038344 526 62655 T162 S S R S D S G T R A L C V R D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P49762 832 95705 A376 A G G G G G G A A G L Q Y D P
Honey Bee Apis mellifera XP_395279 439 51412 P75 D R H R H R S P S S R S Q S P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P51567 427 49548 S63 A P S D N S S S L C V K G V A
Baker's Yeast Sacchar. cerevisiae P32350 737 83824 L232 T G S C A K T L E G N K A V N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 76.6 97.9 59.4 N.A. 88.8 76 N.A. N.A. 65.8 53.2 51 N.A. 34 43.2 N.A. N.A.
Protein Similarity: 100 76.6 98.2 59.5 N.A. 89.6 76.3 N.A. N.A. 70.6 63.4 63.3 N.A. 49.8 53.9 N.A. N.A.
P-Site Identity: 100 13.3 93.3 6.6 N.A. 86.6 13.3 N.A. N.A. 6.6 13.3 13.3 N.A. 6.6 0 N.A. N.A.
P-Site Similarity: 100 20 93.3 20 N.A. 86.6 20 N.A. N.A. 6.6 33.3 20 N.A. 13.3 0 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 30.7 23.7 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 41.7 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 24 0 16 0 8 0 0 8 8 8 0 0 8 0 8 % A
% Cys: 0 0 8 8 0 0 8 0 0 8 0 8 0 0 0 % C
% Asp: 8 0 0 8 8 24 0 0 0 0 0 8 0 8 8 % D
% Glu: 0 0 0 0 24 0 0 0 8 0 0 0 0 0 0 % E
% Phe: 0 0 24 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 16 8 31 8 8 16 0 24 16 0 0 8 0 0 % G
% His: 0 0 8 0 8 0 0 0 0 0 0 0 0 0 24 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 8 8 0 0 0 8 8 39 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 8 8 0 16 0 0 0 0 % L
% Met: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 0 0 0 0 8 0 0 0 16 % N
% Pro: 24 8 0 0 0 0 0 8 0 8 0 0 0 0 16 % P
% Gln: 0 0 0 0 8 8 16 24 24 0 0 8 8 8 0 % Q
% Arg: 0 16 8 16 0 31 0 8 8 0 16 24 31 31 0 % R
% Ser: 24 62 31 31 24 24 39 16 24 47 47 16 31 39 24 % S
% Thr: 8 0 0 0 0 0 8 8 0 8 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 8 0 8 16 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 16 24 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _