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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLK3 All Species: 12.42
Human Site: Y218 Identified Species: 22.78
UniProt: P49761 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49761 NP_001123500.1 638 73515 Y218 E R R D S D T Y R C E E R S P
Chimpanzee Pan troglodytes XP_001136940 490 58560 K112 K H A H H C H K R R T R S C S
Rhesus Macaque Macaca mulatta XP_001100690 638 73454 Y218 E R R D S D T Y R C E E R S P
Dog Lupus familis XP_535541 381 44762
Cat Felis silvestris
Mouse Mus musculus O35492 638 73779 Y218 E H R D S D T Y R C E E R S P
Rat Rattus norvegicus Q63117 490 58467 K112 K H A H H C H K R R T R S C S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001012542 490 58745 R112 Q H Y C R K R R T R S C S S A
Frog Xenopus laevis NP_001093358 497 58599 H119 L H K S S H K H R T R S G S Y
Zebra Danio Brachydanio rerio NP_001038344 526 62655 T148 H K R R R R R T R S Y S A S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P49762 832 95705 T362 Q Q Q Q H P H T Q F Q N A S A
Honey Bee Apis mellifera XP_395279 439 51412 A61 A R I Y R H H A S S S T S Q D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P51567 427 49548 S49 G Q E I G N I S S F A S S G A
Baker's Yeast Sacchar. cerevisiae P32350 737 83824 E218 V P R V T Q T E N E L L H L T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 76.6 97.9 59.4 N.A. 88.8 76 N.A. N.A. 65.8 53.2 51 N.A. 34 43.2 N.A. N.A.
Protein Similarity: 100 76.6 98.2 59.5 N.A. 89.6 76.3 N.A. N.A. 70.6 63.4 63.3 N.A. 49.8 53.9 N.A. N.A.
P-Site Identity: 100 6.6 100 0 N.A. 93.3 6.6 N.A. N.A. 6.6 20 20 N.A. 6.6 6.6 N.A. N.A.
P-Site Similarity: 100 13.3 100 0 N.A. 93.3 13.3 N.A. N.A. 13.3 33.3 26.6 N.A. 40 6.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 30.7 23.7 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 41.7 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 16 0 0 0 0 8 0 0 8 0 16 0 24 % A
% Cys: 0 0 0 8 0 16 0 0 0 24 0 8 0 16 0 % C
% Asp: 0 0 0 24 0 24 0 0 0 0 0 0 0 0 8 % D
% Glu: 24 0 8 0 0 0 0 8 0 8 24 24 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 16 0 0 0 0 0 % F
% Gly: 8 0 0 0 8 0 0 0 0 0 0 0 8 8 0 % G
% His: 8 39 0 16 24 16 31 8 0 0 0 0 8 0 0 % H
% Ile: 0 0 8 8 0 0 8 0 0 0 0 0 0 0 0 % I
% Lys: 16 8 8 0 0 8 8 16 0 0 0 0 0 0 0 % K
% Leu: 8 0 0 0 0 0 0 0 0 0 8 8 0 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 8 0 0 8 0 0 8 0 0 0 % N
% Pro: 0 8 0 0 0 8 0 0 0 0 0 0 0 0 24 % P
% Gln: 16 16 8 8 0 8 0 0 8 0 8 0 0 8 0 % Q
% Arg: 0 24 39 8 24 8 16 8 54 24 8 16 24 0 0 % R
% Ser: 0 0 0 8 31 0 0 8 16 16 16 24 39 54 24 % S
% Thr: 0 0 0 0 8 0 31 16 8 8 16 8 0 0 8 % T
% Val: 8 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 8 0 0 0 24 0 0 8 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _