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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLK3 All Species: 13.64
Human Site: Y163 Identified Species: 25
UniProt: P49761 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49761 NP_001123500.1 638 73515 Y163 R S P E P D P Y L S Y R W K R
Chimpanzee Pan troglodytes XP_001136940 490 58560 Y57 R S H D R L P Y Q R R Y R E R
Rhesus Macaque Macaca mulatta XP_001100690 638 73454 Y163 R S P E P D P Y L S Y R W K R
Dog Lupus familis XP_535541 381 44762
Cat Felis silvestris
Mouse Mus musculus O35492 638 73779 Y163 R S P E P D P Y L S Y R W K R
Rat Rattus norvegicus Q63117 490 58467 Y57 R S H D R I P Y Q R R Y R E H
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001012542 490 58745 H57 S H D R M P Y H R R Y R D R R
Frog Xenopus laevis NP_001093358 497 58599 R64 K R D T F L G R R R R T R C S
Zebra Danio Brachydanio rerio NP_001038344 526 62655 R93 Y R R L D H S R E R D R D Q N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P49762 832 95705 Q307 Q Q H P Q Q Q Q H Q H S S F G
Honey Bee Apis mellifera XP_395279 439 51412
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P51567 427 49548
Baker's Yeast Sacchar. cerevisiae P32350 737 83824 T163 S N N P G C G T A A T S N S T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 76.6 97.9 59.4 N.A. 88.8 76 N.A. N.A. 65.8 53.2 51 N.A. 34 43.2 N.A. N.A.
Protein Similarity: 100 76.6 98.2 59.5 N.A. 89.6 76.3 N.A. N.A. 70.6 63.4 63.3 N.A. 49.8 53.9 N.A. N.A.
P-Site Identity: 100 33.3 100 0 N.A. 100 26.6 N.A. N.A. 20 0 6.6 N.A. 0 0 N.A. N.A.
P-Site Similarity: 100 46.6 100 0 N.A. 100 40 N.A. N.A. 33.3 6.6 13.3 N.A. 13.3 0 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 30.7 23.7 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 41.7 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 8 8 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 8 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 0 16 16 8 24 0 0 0 0 8 0 16 0 0 % D
% Glu: 0 0 0 24 0 0 0 0 8 0 0 0 0 16 0 % E
% Phe: 0 0 0 0 8 0 0 0 0 0 0 0 0 8 0 % F
% Gly: 0 0 0 0 8 0 16 0 0 0 0 0 0 0 8 % G
% His: 0 8 24 0 0 8 0 8 8 0 8 0 0 0 8 % H
% Ile: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % I
% Lys: 8 0 0 0 0 0 0 0 0 0 0 0 0 24 0 % K
% Leu: 0 0 0 8 0 16 0 0 24 0 0 0 0 0 0 % L
% Met: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 8 0 0 0 0 0 0 0 0 0 8 0 8 % N
% Pro: 0 0 24 16 24 8 39 0 0 0 0 0 0 0 0 % P
% Gln: 8 8 0 0 8 8 8 8 16 8 0 0 0 8 0 % Q
% Arg: 39 16 8 8 16 0 0 16 16 39 24 39 24 8 39 % R
% Ser: 16 39 0 0 0 0 8 0 0 24 0 16 8 8 8 % S
% Thr: 0 0 0 8 0 0 0 8 0 0 8 8 0 0 8 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 24 0 0 % W
% Tyr: 8 0 0 0 0 0 8 39 0 0 31 16 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _