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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLK3 All Species: 15.45
Human Site: S463 Identified Species: 28.33
UniProt: P49761 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49761 NP_001123500.1 638 73515 S463 E K S V K N T S I R V A D F G
Chimpanzee Pan troglodytes XP_001136940 490 58560 T332 T F D H E H H T T I V A T R H
Rhesus Macaque Macaca mulatta XP_001100690 638 73454 S463 E K S V K N T S I R V A D F G
Dog Lupus familis XP_535541 381 44762 T223 T F D H E H H T T I V A T R H
Cat Felis silvestris
Mouse Mus musculus O35492 638 73779 S463 E K S V K N T S I R V A D F G
Rat Rattus norvegicus Q63117 490 58467 T332 T F D H E H H T T I V A T R H
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001012542 490 58745 V332 H E H H T T I V A T R H Y R P
Frog Xenopus laevis NP_001093358 497 58599 I339 D H E Y H T T I V A T R H Y R
Zebra Danio Brachydanio rerio NP_001038344 526 62655 T368 H H S T I V S T R H Y R A P E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P49762 832 95705 D637 V R R V K N T D V R L I D F G
Honey Bee Apis mellifera XP_395279 439 51412 H281 A T F D H E H H S T I V S T R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P51567 427 49548 S269 I K V I D F G S T T Y E R Q D
Baker's Yeast Sacchar. cerevisiae P32350 737 83824 E485 R K I L K N P E I K I I D F G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 76.6 97.9 59.4 N.A. 88.8 76 N.A. N.A. 65.8 53.2 51 N.A. 34 43.2 N.A. N.A.
Protein Similarity: 100 76.6 98.2 59.5 N.A. 89.6 76.3 N.A. N.A. 70.6 63.4 63.3 N.A. 49.8 53.9 N.A. N.A.
P-Site Identity: 100 13.3 100 13.3 N.A. 100 13.3 N.A. N.A. 0 6.6 6.6 N.A. 53.3 0 N.A. N.A.
P-Site Similarity: 100 33.3 100 33.3 N.A. 100 33.3 N.A. N.A. 6.6 26.6 20 N.A. 73.3 6.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 30.7 23.7 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 41.7 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 46.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 0 0 0 8 8 0 47 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 24 8 8 0 0 8 0 0 0 0 39 0 8 % D
% Glu: 24 8 8 0 24 8 0 8 0 0 0 8 0 0 8 % E
% Phe: 0 24 8 0 0 8 0 0 0 0 0 0 0 39 0 % F
% Gly: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 39 % G
% His: 16 16 8 31 16 24 31 8 0 8 0 8 8 0 24 % H
% Ile: 8 0 8 8 8 0 8 8 31 24 16 16 0 0 0 % I
% Lys: 0 39 0 0 39 0 0 0 0 8 0 0 0 0 0 % K
% Leu: 0 0 0 8 0 0 0 0 0 0 8 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 39 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 8 0 0 0 0 0 0 8 8 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % Q
% Arg: 8 8 8 0 0 0 0 0 8 31 8 16 8 31 16 % R
% Ser: 0 0 31 0 0 0 8 31 8 0 0 0 8 0 0 % S
% Thr: 24 8 0 8 8 16 39 31 31 24 8 0 24 8 0 % T
% Val: 8 0 8 31 0 8 0 8 16 0 47 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 0 0 0 16 0 8 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _