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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLK3 All Species: 9.09
Human Site: S273 Identified Species: 16.67
UniProt: P49761 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49761 NP_001123500.1 638 73515 S273 C S S A S S R S Q Q S S K R S
Chimpanzee Pan troglodytes XP_001136940 490 58560 F167 G N L G E G T F G K V V E C L
Rhesus Macaque Macaca mulatta XP_001100690 638 73454 S273 C S S A S S R S Q Q S S K R S
Dog Lupus familis XP_535541 381 44762 F58 G N L G E G T F G K V V E C L
Cat Felis silvestris
Mouse Mus musculus O35492 638 73779 S273 C S S A S S R S Q Q S S K R S
Rat Rattus norvegicus Q63117 490 58467 F167 G N L G E G T F G K V V E C L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001012542 490 58745 V167 G E G T F G K V V E C V D H A
Frog Xenopus laevis NP_001093358 497 58599 K174 L G I G T F G K V V E C L D L
Zebra Danio Brachydanio rerio NP_001038344 526 62655 Q203 G T F G R V M Q C I D H R R G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P49762 832 95705 L417 Q Q Q Q Q S Q L Q Q S N S V I
Honey Bee Apis mellifera XP_395279 439 51412 G116 V L A T L G E G T F G K V V K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P51567 427 49548 M104 R Y K I Y S K M G E G T F G Q
Baker's Yeast Sacchar. cerevisiae P32350 737 83824 R273 K Q I G S S L R K F T S N G S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 76.6 97.9 59.4 N.A. 88.8 76 N.A. N.A. 65.8 53.2 51 N.A. 34 43.2 N.A. N.A.
Protein Similarity: 100 76.6 98.2 59.5 N.A. 89.6 76.3 N.A. N.A. 70.6 63.4 63.3 N.A. 49.8 53.9 N.A. N.A.
P-Site Identity: 100 0 100 0 N.A. 100 0 N.A. N.A. 0 0 6.6 N.A. 26.6 0 N.A. N.A.
P-Site Similarity: 100 20 100 20 N.A. 100 20 N.A. N.A. 20 6.6 20 N.A. 40 6.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 30.7 23.7 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 41.7 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 24 0 0 0 0 0 0 0 0 0 0 8 % A
% Cys: 24 0 0 0 0 0 0 0 8 0 8 8 0 24 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 8 0 8 8 0 % D
% Glu: 0 8 0 0 24 0 8 0 0 16 8 0 24 0 0 % E
% Phe: 0 0 8 0 8 8 0 24 0 16 0 0 8 0 0 % F
% Gly: 39 8 8 47 0 39 8 8 31 0 16 0 0 16 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 8 0 8 0 % H
% Ile: 0 0 16 8 0 0 0 0 0 8 0 0 0 0 8 % I
% Lys: 8 0 8 0 0 0 16 8 8 24 0 8 24 0 8 % K
% Leu: 8 8 24 0 8 0 8 8 0 0 0 0 8 0 31 % L
% Met: 0 0 0 0 0 0 8 8 0 0 0 0 0 0 0 % M
% Asn: 0 24 0 0 0 0 0 0 0 0 0 8 8 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 8 16 8 8 8 0 8 8 31 31 0 0 0 0 8 % Q
% Arg: 8 0 0 0 8 0 24 8 0 0 0 0 8 31 0 % R
% Ser: 0 24 24 0 31 47 0 24 0 0 31 31 8 0 31 % S
% Thr: 0 8 0 16 8 0 24 0 8 0 8 8 0 0 0 % T
% Val: 8 0 0 0 0 8 0 8 16 8 24 31 8 16 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _