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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLD2 All Species: 35.45
Human Site: S45 Identified Species: 52
UniProt: P49005 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49005 NP_001120690.1 469 51289 S45 P F R L G E R S F S R Q Y A H
Chimpanzee Pan troglodytes XP_528027 455 49608 S45 P F R L G E R S F S R Q Y A H
Rhesus Macaque Macaca mulatta XP_001093710 469 51277 S45 P F R L G E R S F S R Q Y A H
Dog Lupus familis XP_539802 469 51364 S45 S F R L G E R S F S R Q Y A H
Cat Felis silvestris
Mouse Mus musculus O35654 469 51350 S45 P F R L G E R S F N R Q Y A H
Rat Rattus norvegicus Q6AXY4 469 51328 S45 P F R L G E R S F N R Q Y A H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520117 471 51420 S45 P F R L G E R S F S R Q Y A H
Chicken Gallus gallus
Frog Xenopus laevis O93610 463 50629 T45 I F R L G E R T F T R Q Y A H
Zebra Danio Brachydanio rerio NP_998468 467 51808 S45 R I G E R S F S R Q Y A H I Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W088 431 47990 H33 Q F F H L Y A H R L A E M T R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q19366 451 50385 I48 L K E L K P R I L E N A E R E
Sea Urchin Strong. purpuratus XP_782368 442 49455 S44 L Y S E R L I S M R P G L E K
Poplar Tree Populus trichocarpa XP_002309305 442 49175 A44 Q Y S Q I Y F A R L H L M R T
Maize Zea mays NP_001168398 435 48508 Y37 G Q Q Y S H I Y F T R L H H M
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O48520 456 51321 S47 M Y R G Q Q Y S Q I Y F A R L
Baker's Yeast Sacchar. cerevisiae P46957 487 55277 D48 Q L C Y K K R D Y G S Q Y Y H
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.8 98.9 93.1 N.A. 94.2 94 N.A. 85.3 N.A. 68.8 66.5 N.A. 40 N.A. 28.3 50.5
Protein Similarity: 100 97 99.5 96.5 N.A. 97 96.8 N.A. 90.8 N.A. 79 79.7 N.A. 56.5 N.A. 50.1 66.3
P-Site Identity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 100 N.A. 80 6.6 N.A. 6.6 N.A. 13.3 6.6
P-Site Similarity: 100 100 100 93.3 N.A. 100 100 N.A. 100 N.A. 93.3 20 N.A. 13.3 N.A. 13.3 13.3
Percent
Protein Identity: 41.5 38.8 N.A. 39.6 25.4 N.A.
Protein Similarity: 56.9 56.9 N.A. 57.1 48 N.A.
P-Site Identity: 0 13.3 N.A. 13.3 26.6 N.A.
P-Site Similarity: 13.3 33.3 N.A. 26.6 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 7 7 0 0 7 13 7 50 0 % A
% Cys: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % D
% Glu: 0 0 7 13 0 50 0 0 0 7 0 7 7 7 7 % E
% Phe: 0 57 7 0 0 0 13 0 57 0 0 7 0 0 0 % F
% Gly: 7 0 7 7 50 0 0 0 0 7 0 7 0 0 0 % G
% His: 0 0 0 7 0 7 0 7 0 0 7 0 13 7 57 % H
% Ile: 7 7 0 0 7 0 13 7 0 7 0 0 0 7 0 % I
% Lys: 0 7 0 0 13 7 0 0 0 0 0 0 0 0 7 % K
% Leu: 13 7 0 57 7 7 0 0 7 13 0 13 7 0 7 % L
% Met: 7 0 0 0 0 0 0 0 7 0 0 0 13 0 7 % M
% Asn: 0 0 0 0 0 0 0 0 0 13 7 0 0 0 0 % N
% Pro: 38 0 0 0 0 7 0 0 0 0 7 0 0 0 0 % P
% Gln: 19 7 7 7 7 7 0 0 7 7 0 57 0 0 0 % Q
% Arg: 7 0 57 0 13 0 63 0 19 7 57 0 0 19 7 % R
% Ser: 7 0 13 0 7 7 0 63 0 32 7 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 7 0 13 0 0 0 7 7 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 19 0 13 0 13 7 7 7 0 13 0 57 7 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _