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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IDH2
All Species:
14.55
Human Site:
T27
Identified Species:
26.67
UniProt:
P48735
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48735
NP_002159.2
452
50909
T27
A
W
A
P
A
A
L
T
A
P
T
S
Q
E
Q
Chimpanzee
Pan troglodytes
XP_510589
452
50861
T27
A
W
A
P
A
A
L
T
A
P
T
S
Q
E
Q
Rhesus Macaque
Macaca mulatta
XP_001095686
452
50865
T27
A
W
A
P
A
A
L
T
A
P
T
S
Q
E
Q
Dog
Lupus familis
XP_536192
517
57031
A79
G
R
G
G
G
S
A
A
A
A
P
L
E
E
S
Cat
Felis silvestris
Mouse
Mus musculus
P54071
452
50888
T27
T
W
A
P
A
A
L
T
V
P
S
W
P
E
Q
Rat
Rattus norvegicus
P56574
452
50949
N27
T
W
A
P
A
A
L
N
V
P
S
W
P
E
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507484
450
50551
S31
G
E
K
V
N
T
R
S
E
C
H
L
L
M
D
Chicken
Gallus gallus
NP_001026770
452
50451
T28
C
T
P
P
A
A
C
T
A
L
G
P
P
G
Q
Frog
Xenopus laevis
NP_001080321
454
50741
A27
G
K
N
P
G
V
L
A
P
A
L
S
Q
Q
L
Zebra Danio
Brachydanio rerio
NP_955858
449
50378
P27
K
S
P
A
V
L
A
P
A
C
Q
S
L
Q
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_509875
435
49027
I27
A
T
Q
E
R
Q
K
I
K
V
D
N
P
V
V
Sea Urchin
Strong. purpuratus
XP_001176537
449
50176
G27
S
P
R
C
V
Q
S
G
V
A
L
S
S
T
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P41939
412
46544
I22
G
D
E
Q
T
R
I
I
W
H
L
I
R
D
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.5
79.8
N.A.
95.1
94.6
N.A.
82.5
88.7
86.5
84
N.A.
N.A.
N.A.
65.7
69.9
Protein Similarity:
100
99.7
99.5
83.9
N.A.
97.1
96.9
N.A.
86.7
93.5
92.2
92
N.A.
N.A.
N.A.
76.3
81.6
P-Site Identity:
100
100
100
13.3
N.A.
66.6
60
N.A.
0
40
26.6
20
N.A.
N.A.
N.A.
6.6
13.3
P-Site Similarity:
100
100
100
26.6
N.A.
73.3
66.6
N.A.
6.6
40
33.3
26.6
N.A.
N.A.
N.A.
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
58.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
71.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
31
0
39
8
47
47
16
16
47
24
0
0
0
0
0
% A
% Cys:
8
0
0
8
0
0
8
0
0
16
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
0
0
0
0
0
8
0
0
8
8
% D
% Glu:
0
8
8
8
0
0
0
0
8
0
0
0
8
47
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
31
0
8
8
16
0
0
8
0
0
8
0
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
8
16
0
0
0
8
0
0
0
% I
% Lys:
8
8
8
0
0
0
8
0
8
0
0
0
0
0
8
% K
% Leu:
0
0
0
0
0
8
47
0
0
8
24
16
16
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
8
0
8
0
0
8
0
0
0
8
0
0
0
% N
% Pro:
0
8
16
54
0
0
0
8
8
39
8
8
31
0
0
% P
% Gln:
0
0
8
8
0
16
0
0
0
0
8
0
31
16
62
% Q
% Arg:
0
8
8
0
8
8
8
0
0
0
0
0
8
0
0
% R
% Ser:
8
8
0
0
0
8
8
8
0
0
16
47
8
0
8
% S
% Thr:
16
16
0
0
8
8
0
39
0
0
24
0
0
8
0
% T
% Val:
0
0
0
8
16
8
0
0
24
8
0
0
0
8
8
% V
% Trp:
0
39
0
0
0
0
0
0
8
0
0
16
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _