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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NES All Species: 13.94
Human Site: S659 Identified Species: 38.33
UniProt: P48681 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P48681 NP_006608.1 1621 177439 S659 E N Q E L V S S L Q E N L E S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001116693 1619 177293 S659 E N Q E L V S S L Q E N L E S
Dog Lupus familis XP_547531 1720 190097 S667 E N Q E L V R S L E E N F E S
Cat Felis silvestris
Mouse Mus musculus Q6P5H2 1864 207106 S688 E D Q R F P R S P E E D Q Q A
Rat Rattus norvegicus P21263 1893 208779 P730 S Q E S L R S P E E E D Q E A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518179 1378 147909 A511 E K A D P R A A G T K N E E A
Chicken Gallus gallus NP_990364 1840 202262 E712 T G R A R D D E G E E E D K G
Frog Xenopus laevis Q01550 1744 199544 T704 K L F E N K S T E D Q L I T N
Zebra Danio Brachydanio rerio XP_001919922 1265 143381 T402 P P S S T S M T E K T E D H I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 92.5 57.9 N.A. 50.3 50.1 N.A. 23 26.7 22.3 21.5 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 N.A. 94.6 68.9 N.A. 61.5 61.1 N.A. 38.3 42.5 40.5 40.1 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 N.A. 100 80 N.A. 26.6 26.6 N.A. 20 6.6 13.3 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 N.A. 100 86.6 N.A. 60 53.3 N.A. 53.3 26.6 46.6 13.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 12 12 0 0 12 12 0 0 0 0 0 0 34 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 12 0 12 0 12 12 0 0 12 0 23 23 0 0 % D
% Glu: 56 0 12 45 0 0 0 12 34 45 67 23 12 56 0 % E
% Phe: 0 0 12 0 12 0 0 0 0 0 0 0 12 0 0 % F
% Gly: 0 12 0 0 0 0 0 0 23 0 0 0 0 0 12 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 12 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 12 0 12 % I
% Lys: 12 12 0 0 0 12 0 0 0 12 12 0 0 12 0 % K
% Leu: 0 12 0 0 45 0 0 0 34 0 0 12 23 0 0 % L
% Met: 0 0 0 0 0 0 12 0 0 0 0 0 0 0 0 % M
% Asn: 0 34 0 0 12 0 0 0 0 0 0 45 0 0 12 % N
% Pro: 12 12 0 0 12 12 0 12 12 0 0 0 0 0 0 % P
% Gln: 0 12 45 0 0 0 0 0 0 23 12 0 23 12 0 % Q
% Arg: 0 0 12 12 12 23 23 0 0 0 0 0 0 0 0 % R
% Ser: 12 0 12 23 0 12 45 45 0 0 0 0 0 0 34 % S
% Thr: 12 0 0 0 12 0 0 23 0 12 12 0 0 12 0 % T
% Val: 0 0 0 0 0 34 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _