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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LSS
All Species:
24.55
Human Site:
Y641
Identified Species:
45
UniProt:
P48449
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48449
NP_001001438.1
732
83309
Y641
E
S
C
E
E
R
R
Y
L
Q
S
A
Q
S
Q
Chimpanzee
Pan troglodytes
XP_001159379
732
83231
Y641
E
S
C
E
E
R
R
Y
V
Q
S
A
Q
S
Q
Rhesus Macaque
Macaca mulatta
XP_001098607
732
83143
Y641
E
S
C
E
E
R
R
Y
V
Q
S
A
Q
S
Q
Dog
Lupus familis
XP_548733
654
72679
R597
E
A
L
E
R
G
V
R
C
L
L
R
K
Q
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8BLN5
733
83123
Y642
E
S
C
E
Q
R
R
Y
V
Q
S
A
R
S
Q
Rat
Rattus norvegicus
P48450
733
83282
Y642
E
S
C
E
Q
R
R
Y
V
Q
S
A
G
S
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514164
568
63937
D511
D
K
Q
L
P
N
G
D
W
P
Q
D
N
S
G
Chicken
Gallus gallus
NP_001006514
676
76923
S619
V
A
G
V
F
N
K
S
C
A
I
S
Y
T
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001077036
735
83649
Y642
E
S
C
E
Q
R
R
Y
V
Q
S
S
S
S
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001193804
671
77348
G612
M
S
R
Q
S
E
N
G
D
W
P
Q
E
N
I
Poplar Tree
Populus trichocarpa
XP_002308131
761
86469
I672
Q
N
K
T
Y
S
N
I
E
G
N
R
A
H
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P38605
759
86015
L670
Q
D
K
V
Y
S
N
L
D
G
N
R
S
H
V
Baker's Yeast
Sacchar. cerevisiae
P38604
731
83442
S647
E
L
H
S
Y
V
D
S
E
K
S
L
V
V
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.4
47.8
N.A.
85.5
84.3
N.A.
57.3
69.8
N.A.
75.2
N.A.
N.A.
N.A.
N.A.
46.3
Protein Similarity:
100
99.4
99
59.9
N.A.
92.5
91.6
N.A.
64.6
78.4
N.A.
86.1
N.A.
N.A.
N.A.
N.A.
62.7
P-Site Identity:
100
93.3
93.3
13.3
N.A.
80
80
N.A.
6.6
0
N.A.
73.3
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
26.6
N.A.
100
93.3
N.A.
13.3
26.6
N.A.
93.3
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
44.2
N.A.
N.A.
44.4
40.8
N.A.
Protein Similarity:
60.3
N.A.
N.A.
61.1
58
N.A.
P-Site Identity:
0
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
20
N.A.
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
0
0
0
0
0
8
0
39
8
0
8
% A
% Cys:
0
0
47
0
0
0
0
0
16
0
0
0
0
0
0
% C
% Asp:
8
8
0
0
0
0
8
8
16
0
0
8
0
0
0
% D
% Glu:
62
0
0
54
24
8
0
0
16
0
0
0
8
0
0
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
0
8
8
8
0
16
0
0
8
0
8
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
0
0
16
0
% H
% Ile:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
8
% I
% Lys:
0
8
16
0
0
0
8
0
0
8
0
0
8
0
0
% K
% Leu:
0
8
8
8
0
0
0
8
8
8
8
8
0
0
8
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
16
24
0
0
0
16
0
8
8
0
% N
% Pro:
0
0
0
0
8
0
0
0
0
8
8
0
0
0
0
% P
% Gln:
16
0
8
8
24
0
0
0
0
47
8
8
24
8
54
% Q
% Arg:
0
0
8
0
8
47
47
8
0
0
0
24
8
0
0
% R
% Ser:
0
54
0
8
8
16
0
16
0
0
54
16
16
54
0
% S
% Thr:
0
0
0
8
0
0
0
0
0
0
0
0
0
8
0
% T
% Val:
8
0
0
16
0
8
8
0
39
0
0
0
8
8
16
% V
% Trp:
0
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% W
% Tyr:
0
0
0
0
24
0
0
47
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _