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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIP4K2A
All Species:
22.73
Human Site:
Y246
Identified Species:
50
UniProt:
P48426
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48426
NP_005019.2
406
46225
Y246
I
N
E
G
Q
K
I
Y
I
D
D
N
N
K
K
Chimpanzee
Pan troglodytes
XP_001145662
380
43525
D247
L
A
Q
L
K
L
M
D
Y
S
L
L
V
G
I
Rhesus Macaque
Macaca mulatta
XP_001099389
382
43672
D249
L
A
Q
L
K
L
M
D
Y
S
L
L
V
G
I
Dog
Lupus familis
XP_548154
416
47327
H251
L
N
E
G
Q
K
L
H
V
G
E
E
S
K
K
Cat
Felis silvestris
Mouse
Mus musculus
O70172
405
46133
Y246
I
N
E
G
Q
K
I
Y
I
D
D
N
N
K
K
Rat
Rattus norvegicus
Q9R0I8
406
46191
Y246
I
N
E
G
Q
K
I
Y
I
D
D
S
N
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510625
479
54696
Y315
I
N
D
G
Q
K
I
Y
I
D
D
N
N
K
K
Chicken
Gallus gallus
Q5F356
405
46073
H245
I
N
D
G
Q
K
I
H
I
D
E
N
N
K
R
Frog
Xenopus laevis
Q5PQ01
419
47633
Y257
L
N
K
S
Q
K
V
Y
V
D
E
E
Q
K
R
Zebra Danio
Brachydanio rerio
Q6IQE1
416
47361
Y249
R
N
N
M
Q
K
V
Y
V
T
E
E
Q
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_392797
416
47916
Y244
V
K
E
G
M
K
I
Y
I
G
E
E
A
K
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.1
89.9
75.9
N.A.
98
97.5
N.A.
76.8
93.3
67.3
64.6
N.A.
N.A.
59.6
N.A.
N.A.
Protein Similarity:
100
91.6
90.3
87.2
N.A.
99.2
99.2
N.A.
79.3
97
79.7
77.8
N.A.
N.A.
73.3
N.A.
N.A.
P-Site Identity:
100
0
0
46.6
N.A.
100
93.3
N.A.
93.3
73.3
40
33.3
N.A.
N.A.
46.6
N.A.
N.A.
P-Site Similarity:
100
26.6
26.6
86.6
N.A.
100
100
N.A.
100
100
80
60
N.A.
N.A.
60
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
19
0
0
0
0
0
0
0
0
0
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
19
0
0
0
0
19
0
55
37
0
0
0
0
% D
% Glu:
0
0
46
0
0
0
0
0
0
0
46
37
0
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
64
0
0
0
0
0
19
0
0
0
19
0
% G
% His:
0
0
0
0
0
0
0
19
0
0
0
0
0
0
0
% H
% Ile:
46
0
0
0
0
0
55
0
55
0
0
0
0
0
19
% I
% Lys:
0
10
10
0
19
82
0
0
0
0
0
0
0
82
46
% K
% Leu:
37
0
0
19
0
19
10
0
0
0
19
19
0
0
0
% L
% Met:
0
0
0
10
10
0
19
0
0
0
0
0
0
0
0
% M
% Asn:
0
73
10
0
0
0
0
0
0
0
0
37
46
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
19
0
73
0
0
0
0
0
0
0
19
0
0
% Q
% Arg:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
19
% R
% Ser:
0
0
0
10
0
0
0
0
0
19
0
10
10
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
10
% T
% Val:
10
0
0
0
0
0
19
0
28
0
0
0
19
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
64
19
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _