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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PREP
All Species:
50.91
Human Site:
S220
Identified Species:
86.15
UniProt:
P48147
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48147
NP_002717.3
710
80700
S220
H
V
L
G
T
D
Q
S
E
D
I
L
C
A
E
Chimpanzee
Pan troglodytes
XP_518657
710
80695
S220
H
V
L
G
T
D
Q
S
E
D
I
L
C
A
E
Rhesus Macaque
Macaca mulatta
XP_001087580
710
80763
S220
H
V
L
G
T
D
Q
S
E
D
I
L
C
A
E
Dog
Lupus familis
XP_854289
651
73567
L213
G
I
S
G
M
L
G
L
S
P
G
I
L
K
W
Cat
Felis silvestris
Mouse
Mus musculus
Q9QUR6
710
80733
S220
H
V
L
G
T
D
Q
S
E
D
I
L
C
A
E
Rat
Rattus norvegicus
O70196
710
80723
S220
H
V
L
G
T
D
Q
S
E
D
V
L
C
A
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505853
734
82688
S244
H
V
L
G
T
D
Q
S
E
D
I
L
C
A
E
Chicken
Gallus gallus
NP_001006410
710
80772
S220
H
V
L
G
T
N
Q
S
E
D
I
L
C
A
E
Frog
Xenopus laevis
NP_001084314
712
80625
S223
H
V
L
G
T
S
Q
S
D
D
V
L
C
A
E
Zebra Danio
Brachydanio rerio
NP_001018589
709
80318
S219
H
V
L
G
T
P
Q
S
Q
D
V
L
C
A
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395364
765
87125
S280
H
I
I
G
T
P
Q
S
E
D
I
I
V
V
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002306966
733
82736
S232
H
F
L
G
T
D
Q
S
E
D
I
L
C
W
R
Maize
Zea mays
NP_001130392
731
81856
S230
H
V
L
G
S
D
Q
S
E
D
I
L
C
W
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177741
795
89386
S294
H
F
I
G
T
D
Q
S
Q
D
I
L
C
W
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.8
87.6
N.A.
95.7
95.2
N.A.
86.2
90.2
81.5
76
N.A.
N.A.
55.2
N.A.
N.A.
Protein Similarity:
100
100
99.5
89.5
N.A.
98.5
98.3
N.A.
92.3
95.9
91
89.3
N.A.
N.A.
70.5
N.A.
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
100
93.3
N.A.
100
93.3
80
80
N.A.
N.A.
60
N.A.
N.A.
P-Site Similarity:
100
100
100
20
N.A.
100
100
N.A.
100
100
93.3
93.3
N.A.
N.A.
80
N.A.
N.A.
Percent
Protein Identity:
55.6
54.5
N.A.
52.4
N.A.
N.A.
Protein Similarity:
73.2
72.5
N.A.
68.1
N.A.
N.A.
P-Site Identity:
80
80
N.A.
66.6
N.A.
N.A.
P-Site Similarity:
80
93.3
N.A.
80
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
65
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
86
0
0
% C
% Asp:
0
0
0
0
0
65
0
0
8
93
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
72
0
0
0
0
0
72
% E
% Phe:
0
15
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
100
0
0
8
0
0
0
8
0
0
0
0
% G
% His:
93
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
15
15
0
0
0
0
0
0
0
72
15
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% K
% Leu:
0
0
79
0
0
8
0
8
0
0
0
86
8
0
0
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
15
0
0
0
8
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
93
0
15
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
15
% R
% Ser:
0
0
8
0
8
8
0
93
8
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
86
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
72
0
0
0
0
0
0
0
0
22
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
22
8
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _