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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC6A8 All Species: 14.24
Human Site: S222 Identified Species: 28.48
UniProt: P48029 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P48029 NP_001136277.1 635 70523 S222 E N K V L R L S G G L E V P G
Chimpanzee Pan troglodytes XP_529227 517 57747 A124 D C A N A S L A N L T C D Q L
Rhesus Macaque Macaca mulatta Q9MYX0 630 70239 T206 S C K N S W N T G N C T N Y F
Dog Lupus familis XP_549362 569 63441 C176 C W V L V Y F C V W K G V K S
Cat Felis silvestris
Mouse Mus musculus Q8VBW1 640 70981 S222 E N K V L R L S T G L E V P G
Rat Rattus norvegicus P28570 635 70613 S222 E N K V L R L S T G L E V P G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521283 733 81919 E324 L S L S S G I E D L G I L K W
Chicken Gallus gallus NP_001025771 631 71046 E211 L S L S S G I E D I G I I K W
Frog Xenopus laevis A7Y2W8 633 71004 F206 I S E D I G D F G E V Q L P L
Zebra Danio Brachydanio rerio XP_695932 652 73002 S239 E N K V L N I S D G L D E P G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P51905 622 69307 T208 T E N C M Q V T S E N F T E L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q03614 615 69247 I220 N A P N S H V I R S V T D L G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 80.7 40.3 83.1 N.A. 98.1 98.4 N.A. 49.2 52.9 40.1 73.7 N.A. 41.7 N.A. 40.4 N.A.
Protein Similarity: 100 80.9 61 84.7 N.A. 98.2 98.7 N.A. 62.8 68.8 61 83.4 N.A. 60 N.A. 59.3 N.A.
P-Site Identity: 100 6.6 13.3 6.6 N.A. 93.3 93.3 N.A. 0 0 13.3 66.6 N.A. 0 N.A. 6.6 N.A.
P-Site Similarity: 100 20 20 20 N.A. 93.3 93.3 N.A. 20 20 53.3 80 N.A. 26.6 N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 9 0 9 0 0 9 0 0 0 0 0 0 0 % A
% Cys: 9 17 0 9 0 0 0 9 0 0 9 9 0 0 0 % C
% Asp: 9 0 0 9 0 0 9 0 25 0 0 9 17 0 0 % D
% Glu: 34 9 9 0 0 0 0 17 0 17 0 25 9 9 0 % E
% Phe: 0 0 0 0 0 0 9 9 0 0 0 9 0 0 9 % F
% Gly: 0 0 0 0 0 25 0 0 25 34 17 9 0 0 42 % G
% His: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % H
% Ile: 9 0 0 0 9 0 25 9 0 9 0 17 9 0 0 % I
% Lys: 0 0 42 0 0 0 0 0 0 0 9 0 0 25 0 % K
% Leu: 17 0 17 9 34 0 34 0 0 17 34 0 17 9 25 % L
% Met: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 9 34 9 25 0 9 9 0 9 9 9 0 9 0 0 % N
% Pro: 0 0 9 0 0 0 0 0 0 0 0 0 0 42 0 % P
% Gln: 0 0 0 0 0 9 0 0 0 0 0 9 0 9 0 % Q
% Arg: 0 0 0 0 0 25 0 0 9 0 0 0 0 0 0 % R
% Ser: 9 25 0 17 34 9 0 34 9 9 0 0 0 0 9 % S
% Thr: 9 0 0 0 0 0 0 17 17 0 9 17 9 0 0 % T
% Val: 0 0 9 34 9 0 17 0 9 0 17 0 34 0 0 % V
% Trp: 0 9 0 0 0 9 0 0 0 9 0 0 0 0 17 % W
% Tyr: 0 0 0 0 0 9 0 0 0 0 0 0 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _