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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEDD4
All Species:
4.55
Human Site:
T648
Identified Species:
8.33
UniProt:
P46934
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46934
NP_006145.2
1319
149059
T648
P
T
P
Q
D
N
L
T
D
A
E
N
G
N
I
Chimpanzee
Pan troglodytes
XP_523083
895
103693
P311
G
N
S
A
M
S
Q
P
A
S
S
S
N
H
S
Rhesus Macaque
Macaca mulatta
XP_001088005
1077
123165
S493
G
N
S
A
T
S
Q
S
A
S
S
S
N
H
S
Dog
Lupus familis
XP_851423
1251
141207
S639
A
F
P
S
P
P
A
S
N
N
L
D
V
Q
T
Cat
Felis silvestris
Mouse
Mus musculus
P46935
887
102688
T303
L
Q
A
Q
R
A
F
T
T
R
R
Q
I
S
E
Rat
Rattus norvegicus
Q62940
887
102376
R303
H
G
A
F
T
T
R
R
Q
I
S
E
D
V
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511197
1255
141275
T641
Q
N
I
Q
S
P
P
T
P
S
N
F
D
I
Q
Chicken
Gallus gallus
XP_424462
1045
119140
G460
T
T
P
G
L
P
S
G
W
E
E
R
K
D
A
Frog
Xenopus laevis
Q2TAS2
751
86306
R167
P
D
G
W
E
E
R
R
T
A
S
G
R
I
Q
Zebra Danio
Brachydanio rerio
A9JRZ0
765
87445
R181
Q
Y
L
N
H
I
T
R
S
T
Q
W
E
R
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVI3
1007
114856
A423
T
N
P
F
T
R
R
A
A
G
N
M
A
G
G
Honey Bee
Apis mellifera
XP_395191
782
90150
E198
R
P
L
P
P
G
W
E
E
R
Q
D
A
N
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39940
809
91798
E225
T
R
Q
Y
S
S
F
E
D
Q
Y
G
R
L
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
65.1
67.5
86.5
N.A.
56.4
56
N.A.
70
40.6
27.6
28.2
N.A.
35.9
36.2
N.A.
N.A.
Protein Similarity:
100
67.2
72.4
89.8
N.A.
60.9
61.1
N.A.
80
53.7
40.1
39.7
N.A.
49.7
46.5
N.A.
N.A.
P-Site Identity:
100
0
0
6.6
N.A.
13.3
0
N.A.
13.3
20
13.3
0
N.A.
6.6
6.6
N.A.
N.A.
P-Site Similarity:
100
26.6
33.3
26.6
N.A.
20
0
N.A.
20
26.6
20
6.6
N.A.
6.6
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
30.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
16
16
0
8
8
8
24
16
0
0
16
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
8
0
0
0
16
0
0
16
16
8
8
% D
% Glu:
0
0
0
0
8
8
0
16
8
8
16
8
8
0
8
% E
% Phe:
0
8
0
16
0
0
16
0
0
0
0
8
0
0
0
% F
% Gly:
16
8
8
8
0
8
0
8
0
8
0
16
8
8
16
% G
% His:
8
0
0
0
8
0
0
0
0
0
0
0
0
16
0
% H
% Ile:
0
0
8
0
0
8
0
0
0
8
0
0
8
16
8
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% K
% Leu:
8
0
16
0
8
0
8
0
0
0
8
0
0
8
0
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
31
0
8
0
8
0
0
8
8
16
8
16
16
0
% N
% Pro:
16
8
31
8
16
24
8
8
8
0
0
0
0
0
16
% P
% Gln:
16
8
8
24
0
0
16
0
8
8
16
8
0
8
16
% Q
% Arg:
8
8
0
0
8
8
24
24
0
16
8
8
16
8
0
% R
% Ser:
0
0
16
8
16
24
8
16
8
24
31
16
0
8
16
% S
% Thr:
24
16
0
0
24
8
8
24
16
8
0
0
0
0
8
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% V
% Trp:
0
0
0
8
0
0
8
0
8
0
0
8
0
0
0
% W
% Tyr:
0
8
0
8
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _