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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEDD4
All Species:
4.55
Human Site:
S456
Identified Species:
8.33
UniProt:
P46934
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46934
NP_006145.2
1319
149059
S456
N
H
G
I
L
R
R
S
I
S
L
G
G
A
Y
Chimpanzee
Pan troglodytes
XP_523083
895
103693
L139
K
S
R
V
K
G
Y
L
R
L
K
M
T
Y
L
Rhesus Macaque
Macaca mulatta
XP_001088005
1077
123165
L321
K
S
R
V
K
G
Y
L
R
L
K
M
T
Y
L
Dog
Lupus familis
XP_851423
1251
141207
S456
N
H
A
I
L
Q
R
S
V
S
L
G
G
T
Y
Cat
Felis silvestris
Mouse
Mus musculus
P46935
887
102688
W131
K
K
S
L
N
P
K
W
N
E
E
I
L
F
R
Rat
Rattus norvegicus
Q62940
887
102376
E131
L
N
P
K
W
N
E
E
I
L
F
R
V
L
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511197
1255
141275
I463
H
H
L
L
Q
R
S
I
S
L
E
G
S
Y
Q
Chicken
Gallus gallus
XP_424462
1045
119140
T288
Y
V
N
H
N
N
R
T
T
Q
W
H
R
P
S
Frog
Xenopus laevis
Q2TAS2
751
86306
Zebra Danio
Brachydanio rerio
A9JRZ0
765
87445
N9
S
N
Q
G
V
R
R
N
G
P
V
K
L
R
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVI3
1007
114856
G251
G
H
D
A
L
P
A
G
W
E
E
R
Q
D
A
Honey Bee
Apis mellifera
XP_395191
782
90150
K26
S
R
D
E
A
T
R
K
L
R
L
K
V
I
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39940
809
91798
E53
T
L
N
P
Y
W
N
E
T
F
K
F
D
D
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
65.1
67.5
86.5
N.A.
56.4
56
N.A.
70
40.6
27.6
28.2
N.A.
35.9
36.2
N.A.
N.A.
Protein Similarity:
100
67.2
72.4
89.8
N.A.
60.9
61.1
N.A.
80
53.7
40.1
39.7
N.A.
49.7
46.5
N.A.
N.A.
P-Site Identity:
100
0
0
73.3
N.A.
0
6.6
N.A.
20
6.6
0
13.3
N.A.
13.3
13.3
N.A.
N.A.
P-Site Similarity:
100
6.6
6.6
86.6
N.A.
13.3
13.3
N.A.
33.3
13.3
0
46.6
N.A.
13.3
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
30.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
8
0
8
0
0
0
0
0
0
8
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
16
0
0
0
0
0
0
0
0
0
8
16
0
% D
% Glu:
0
0
0
8
0
0
8
16
0
16
24
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
8
8
0
8
0
% F
% Gly:
8
0
8
8
0
16
0
8
8
0
0
24
16
0
0
% G
% His:
8
31
0
8
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
0
16
0
0
0
8
16
0
0
8
0
8
8
% I
% Lys:
24
8
0
8
16
0
8
8
0
0
24
16
0
0
0
% K
% Leu:
8
8
8
16
24
0
0
16
8
31
24
0
16
8
24
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
16
0
0
0
% M
% Asn:
16
16
16
0
16
16
8
8
8
0
0
0
0
0
0
% N
% Pro:
0
0
8
8
0
16
0
0
0
8
0
0
0
8
8
% P
% Gln:
0
0
8
0
8
8
0
0
0
8
0
0
8
0
8
% Q
% Arg:
0
8
16
0
0
24
39
0
16
8
0
16
8
8
8
% R
% Ser:
16
16
8
0
0
0
8
16
8
16
0
0
8
0
8
% S
% Thr:
8
0
0
0
0
8
0
8
16
0
0
0
16
8
0
% T
% Val:
0
8
0
16
8
0
0
0
8
0
8
0
16
0
0
% V
% Trp:
0
0
0
0
8
8
0
8
8
0
8
0
0
0
0
% W
% Tyr:
8
0
0
0
8
0
16
0
0
0
0
0
0
24
16
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _