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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K4
All Species:
28.48
Human Site:
Y358
Identified Species:
44.76
UniProt:
P45985
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45985
NP_003001.1
399
44288
Y358
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
L352
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
Rhesus Macaque
Macaca mulatta
XP_001114292
410
45566
Y369
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
Dog
Lupus familis
XP_546627
413
46697
Y372
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
Cat
Felis silvestris
Mouse
Mus musculus
P47809
397
44095
Y356
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
Rat
Rattus norvegicus
Q4KSH7
419
47517
N372
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90891
398
44059
L358
N
P
A
E
R
A
D
L
K
M
L
M
N
H
T
Frog
Xenopus laevis
Q07192
446
50082
Y405
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
C321
F
V
D
F
T
S
Q
C
L
R
K
N
S
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477353
424
47515
Y378
K
E
S
D
R
P
K
Y
S
R
L
L
E
M
P
Honey Bee
Apis mellifera
XP_394054
436
49631
Y393
E
E
T
Q
R
P
K
Y
N
K
L
L
E
H
P
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
T323
R
H
R
P
K
Y
D
T
L
K
S
F
D
F
Y
Sea Urchin
Strong. purpuratus
XP_794490
382
43817
K342
K
C
L
T
K
D
E
K
Y
R
P
K
Y
K
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
P316
S
A
C
I
Q
K
D
P
P
A
R
A
S
S
L
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
Y614
I
P
E
R
R
P
T
Y
A
A
L
T
E
H
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.3
97.3
89.3
N.A.
97.9
41.7
N.A.
N.A.
36.5
77.3
48.3
N.A.
54
55.9
44.6
55.8
Protein Similarity:
100
53.6
97.3
90.5
N.A.
98.2
57.2
N.A.
N.A.
53.8
80.9
64.4
N.A.
65.8
68.8
61.6
71.1
P-Site Identity:
100
26.6
100
100
N.A.
100
13.3
N.A.
N.A.
26.6
100
0
N.A.
60
60
0
0
P-Site Similarity:
100
60
100
100
N.A.
100
20
N.A.
N.A.
53.3
100
6.6
N.A.
66.6
93.3
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
31
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.3
38.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
14
0
0
14
0
0
7
14
0
7
0
0
7
% A
% Cys:
0
7
7
0
0
0
0
7
0
0
0
0
0
0
0
% C
% Asp:
34
0
7
7
0
7
27
0
0
0
0
0
7
0
0
% D
% Glu:
7
47
7
14
0
0
7
0
0
34
0
7
20
0
7
% E
% Phe:
7
0
0
7
0
0
0
0
0
0
0
7
0
7
7
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
7
7
0
0
0
0
0
0
0
0
0
0
7
60
0
% H
% Ile:
7
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
14
0
7
34
14
14
47
7
54
14
7
7
34
7
0
% K
% Leu:
0
0
7
0
0
0
0
14
14
7
74
47
0
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
7
0
14
0
7
0
% M
% Asn:
14
0
0
0
0
0
0
7
7
0
0
7
7
0
7
% N
% Pro:
0
20
0
7
7
54
0
7
7
0
7
0
0
0
54
% P
% Gln:
0
0
0
7
7
0
7
0
0
7
0
0
0
0
0
% Q
% Arg:
7
7
7
14
67
0
0
0
0
20
7
0
0
0
0
% R
% Ser:
7
0
40
0
0
7
0
0
7
0
7
0
14
14
0
% S
% Thr:
0
0
7
7
7
0
7
7
0
0
0
7
0
7
7
% T
% Val:
0
7
0
0
0
0
0
0
0
0
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
7
54
7
0
0
0
7
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _