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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K4
All Species:
19.09
Human Site:
Y307
Identified Species:
30
UniProt:
P45985
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45985
NP_003001.1
399
44288
Y307
L
A
T
G
R
F
P
Y
P
K
W
N
S
V
F
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
G301
G
R
P
L
S
S
Y
G
M
D
S
R
P
P
M
Rhesus Macaque
Macaca mulatta
XP_001114292
410
45566
Y318
L
A
T
G
R
F
P
Y
P
K
W
N
S
V
F
Dog
Lupus familis
XP_546627
413
46697
Y321
L
A
T
G
R
F
P
Y
P
K
W
N
S
V
F
Cat
Felis silvestris
Mouse
Mus musculus
P47809
397
44095
Y305
L
A
T
G
R
F
P
Y
P
K
W
N
S
V
F
Rat
Rattus norvegicus
Q4KSH7
419
47517
P321
E
L
A
T
G
Q
F
P
Y
K
N
C
K
T
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90891
398
44059
G307
G
R
P
I
S
G
H
G
M
D
S
R
P
A
M
Frog
Xenopus laevis
Q07192
446
50082
Y354
L
A
T
G
R
F
P
Y
P
K
W
N
S
V
F
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
L270
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477353
424
47515
R327
A
T
G
N
F
P
Y
R
K
W
D
S
V
F
E
Honey Bee
Apis mellifera
XP_394054
436
49631
P342
A
T
G
Y
F
P
Y
P
K
W
N
S
V
F
E
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
W272
G
K
F
P
Y
Q
E
W
N
S
L
F
D
Q
I
Sea Urchin
Strong. purpuratus
XP_794490
382
43817
T291
I
T
M
Y
E
V
A
T
G
E
F
P
Y
P
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
R265
V
L
E
C
A
I
G
R
F
P
Y
L
E
S
E
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
P563
E
M
A
L
G
R
Y
P
Y
P
P
E
T
Y
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.3
97.3
89.3
N.A.
97.9
41.7
N.A.
N.A.
36.5
77.3
48.3
N.A.
54
55.9
44.6
55.8
Protein Similarity:
100
53.6
97.3
90.5
N.A.
98.2
57.2
N.A.
N.A.
53.8
80.9
64.4
N.A.
65.8
68.8
61.6
71.1
P-Site Identity:
100
0
100
100
N.A.
100
6.6
N.A.
N.A.
0
100
0
N.A.
0
0
0
0
P-Site Similarity:
100
0
100
100
N.A.
100
6.6
N.A.
N.A.
0
100
20
N.A.
6.6
6.6
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
31
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.3
38.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
34
14
0
7
0
7
0
0
0
0
0
0
7
0
% A
% Cys:
0
0
0
7
0
0
0
0
0
0
0
7
0
0
0
% C
% Asp:
0
0
0
7
0
0
0
0
0
14
7
0
7
0
14
% D
% Glu:
14
0
7
0
7
0
7
0
0
7
0
7
7
7
20
% E
% Phe:
0
0
7
0
14
34
7
0
7
0
7
7
0
14
34
% F
% Gly:
20
0
14
34
14
7
7
14
14
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
0
7
7
7
0
0
0
7
0
0
7
0
7
% I
% Lys:
0
14
0
0
0
0
0
0
14
40
0
0
7
0
7
% K
% Leu:
34
14
0
14
0
0
0
7
0
0
7
7
0
0
7
% L
% Met:
0
7
7
0
0
0
0
0
14
0
0
7
0
0
14
% M
% Asn:
0
0
0
7
0
0
0
0
7
0
14
34
0
0
0
% N
% Pro:
0
0
14
7
0
14
34
20
34
14
7
7
14
14
0
% P
% Gln:
0
0
0
0
0
14
0
0
0
0
0
0
0
7
0
% Q
% Arg:
0
14
0
0
34
7
0
14
0
0
0
14
0
0
0
% R
% Ser:
0
0
7
0
14
7
7
0
0
7
14
14
34
7
0
% S
% Thr:
0
20
34
7
0
0
0
7
0
0
7
0
7
7
0
% T
% Val:
14
0
0
0
0
7
0
0
0
0
0
0
14
34
0
% V
% Trp:
0
0
0
0
0
7
0
7
0
14
34
0
0
0
0
% W
% Tyr:
0
0
0
14
7
0
27
34
14
0
7
0
7
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _