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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K4
All Species:
20.61
Human Site:
Y191
Identified Species:
32.38
UniProt:
P45985
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45985
NP_003001.1
399
44288
Y191
S
F
D
K
F
Y
K
Y
V
Y
S
V
L
D
D
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
V191
H
K
I
M
H
R
D
V
Q
P
S
N
I
L
V
Rhesus Macaque
Macaca mulatta
XP_001114292
410
45566
Y202
S
F
D
K
F
Y
K
Y
V
Y
S
V
L
D
D
Dog
Lupus familis
XP_546627
413
46697
Y205
S
F
D
K
F
Y
K
Y
V
Y
S
V
L
D
D
Cat
Felis silvestris
Mouse
Mus musculus
P47809
397
44095
Y189
S
F
D
K
F
Y
K
Y
V
Y
S
V
L
D
D
Rat
Rattus norvegicus
Q4KSH7
419
47517
R209
C
A
E
K
L
K
K
R
M
Q
G
P
I
P
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90891
398
44059
V193
H
Q
I
M
H
R
D
V
K
P
S
N
I
L
V
Frog
Xenopus laevis
Q07192
446
50082
Y238
S
F
D
K
F
Y
K
Y
V
Y
S
F
L
D
D
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
D160
W
I
C
M
E
L
M
D
T
S
L
D
K
F
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477353
424
47515
Y211
S
L
D
K
F
Y
K
Y
I
Y
E
K
Q
Q
R
Honey Bee
Apis mellifera
XP_394054
436
49631
F226
S
L
D
I
F
Y
K
F
I
H
E
V
L
K
E
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
N162
K
R
V
Y
M
V
K
N
S
R
L
N
E
N
V
Sea Urchin
Strong. purpuratus
XP_794490
382
43817
V181
L
D
K
F
Y
R
F
V
H
E
V
Q
N
T
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
A155
Y
M
D
R
G
S
L
A
D
V
I
R
Q
V
K
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
I453
I
Y
D
E
S
S
E
I
G
G
I
D
E
P
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.3
97.3
89.3
N.A.
97.9
41.7
N.A.
N.A.
36.5
77.3
48.3
N.A.
54
55.9
44.6
55.8
Protein Similarity:
100
53.6
97.3
90.5
N.A.
98.2
57.2
N.A.
N.A.
53.8
80.9
64.4
N.A.
65.8
68.8
61.6
71.1
P-Site Identity:
100
6.6
100
100
N.A.
100
13.3
N.A.
N.A.
6.6
93.3
0
N.A.
53.3
46.6
6.6
0
P-Site Similarity:
100
13.3
100
100
N.A.
100
40
N.A.
N.A.
13.3
93.3
0
N.A.
60
73.3
13.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
31
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.3
38.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
0
0
7
0
0
0
0
0
0
0
% A
% Cys:
7
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
60
0
0
0
14
7
7
0
0
14
0
34
34
% D
% Glu:
0
0
7
7
7
0
7
0
0
7
14
0
14
0
14
% E
% Phe:
0
34
0
7
47
0
7
7
0
0
0
7
0
7
0
% F
% Gly:
0
0
0
0
7
0
0
0
7
7
7
0
0
0
0
% G
% His:
14
0
0
0
14
0
0
0
7
7
0
0
0
0
0
% H
% Ile:
7
7
14
7
0
0
0
7
14
0
14
0
20
0
0
% I
% Lys:
7
7
7
47
0
7
60
0
7
0
0
7
7
7
7
% K
% Leu:
7
14
0
0
7
7
7
0
0
0
14
0
40
14
0
% L
% Met:
0
7
0
20
7
0
7
0
7
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
7
0
0
0
20
7
7
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
14
0
7
0
14
0
% P
% Gln:
0
7
0
0
0
0
0
0
7
7
0
7
14
7
7
% Q
% Arg:
0
7
0
7
0
20
0
7
0
7
0
7
0
0
7
% R
% Ser:
47
0
0
0
7
14
0
0
7
7
47
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
7
0
0
0
0
7
0
% T
% Val:
0
0
7
0
0
7
0
20
34
7
7
34
0
7
20
% V
% Trp:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
7
0
7
7
47
0
40
0
40
0
0
0
0
14
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _