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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K4
All Species:
15.45
Human Site:
T56
Identified Species:
24.29
UniProt:
P45985
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45985
NP_003001.1
399
44288
T56
A
N
P
P
F
K
S
T
A
R
F
T
L
N
P
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
E62
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
Rhesus Macaque
Macaca mulatta
XP_001114292
410
45566
T67
A
N
P
P
F
K
S
T
A
R
F
T
L
N
P
Dog
Lupus familis
XP_546627
413
46697
T70
A
N
P
P
F
K
S
T
A
R
F
T
L
N
P
Cat
Felis silvestris
Mouse
Mus musculus
P47809
397
44095
T54
A
N
P
P
V
K
S
T
A
R
F
T
L
N
P
Rat
Rattus norvegicus
Q4KSH7
419
47517
M74
P
P
S
R
P
R
H
M
L
G
L
P
S
T
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90891
398
44059
E64
T
Q
K
A
K
V
G
E
L
K
D
D
D
F
E
Frog
Xenopus laevis
Q07192
446
50082
T103
Y
Q
K
Q
D
L
R
T
S
G
A
K
A
L
S
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
R31
M
S
V
P
S
N
V
R
G
K
K
K
L
P
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477353
424
47515
S76
Q
T
P
P
V
A
S
S
Q
V
P
P
V
P
A
Honey Bee
Apis mellifera
XP_394054
436
49631
P91
P
L
S
L
P
K
L
P
V
R
S
C
T
A
V
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
E33
S
L
S
V
N
G
N
E
K
T
L
P
E
E
S
Sea Urchin
Strong. purpuratus
XP_794490
382
43817
R52
R
E
Q
L
N
S
M
R
S
R
S
M
E
S
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
L26
E
S
P
I
S
S
F
L
T
A
S
G
T
F
H
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
G314
S
N
S
G
S
S
G
G
G
G
L
F
A
N
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.3
97.3
89.3
N.A.
97.9
41.7
N.A.
N.A.
36.5
77.3
48.3
N.A.
54
55.9
44.6
55.8
Protein Similarity:
100
53.6
97.3
90.5
N.A.
98.2
57.2
N.A.
N.A.
53.8
80.9
64.4
N.A.
65.8
68.8
61.6
71.1
P-Site Identity:
100
0
100
100
N.A.
93.3
0
N.A.
N.A.
0
6.6
13.3
N.A.
20
13.3
0
6.6
P-Site Similarity:
100
6.6
100
100
N.A.
93.3
6.6
N.A.
N.A.
6.6
13.3
26.6
N.A.
33.3
13.3
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
31
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.3
38.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
27
0
0
7
0
7
0
0
27
7
7
0
14
7
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% C
% Asp:
0
0
0
0
7
0
0
0
0
0
14
14
14
0
0
% D
% Glu:
7
7
0
0
0
0
0
20
0
0
0
0
14
7
14
% E
% Phe:
0
0
0
0
20
0
7
0
0
0
27
7
0
20
7
% F
% Gly:
0
0
0
7
0
7
20
7
14
20
0
7
0
0
0
% G
% His:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
7
% H
% Ile:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
7
% I
% Lys:
0
0
20
0
14
34
0
0
7
20
7
14
0
0
7
% K
% Leu:
0
14
0
14
0
7
7
7
20
0
20
0
34
7
7
% L
% Met:
7
0
0
0
0
0
7
7
0
0
0
7
0
0
0
% M
% Asn:
0
34
0
0
14
7
7
0
0
0
0
0
0
34
0
% N
% Pro:
14
7
40
40
14
0
0
7
0
0
7
20
0
14
27
% P
% Gln:
7
20
7
14
0
0
0
0
7
0
0
0
0
0
0
% Q
% Arg:
7
0
0
7
0
7
7
14
0
40
0
0
0
0
0
% R
% Ser:
14
14
27
0
20
20
34
7
14
0
20
0
7
7
14
% S
% Thr:
14
7
0
0
0
0
0
34
7
7
0
27
14
7
0
% T
% Val:
0
0
7
7
14
14
7
0
7
7
0
0
7
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _